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Is it possible to replace the file after it has been submitted?

There are two cases to be distinguished:

1) The file has not yet been made accessible:

Yes, it is still possible to replace the file. The Editorial Team will assist you with the replacement.

2.) The file has been made accessible:

Replacement is admissible in exceptional cases only and will require specific justification (which would, in general, be based on legal grounds). Such cases will regularly involve document versioning.