The relationship between business and environmental issues in Germany and Europe has changed drastically over the years, with continuous impact by the interaction between the German and European Union political levels. Nowadays, positive environmental impacts envisioned by sustainable entrepreneurship and core business activities, are increasingly being acknowledged by customers, politics, and society as a whole. This lecture will shed some light on the motivating forces behind entrepreneurs’ and businesses’ decision to make a strategic commitment to sustainability. We will also “visit” some best practice examples from Berlin’s thriving “green business” start-up scene and ask how they have creatively overcome market and regulatory barriers to make an environmental and social difference.