Biochemistry

• Advanced Biochemistry A - Current Topics in Nucleic Acid and Protein Biology (5 LP)

  0390bA1.1
  • 216101a Lecture
    Advanced Biochemistry - A: Nucleic Acids and Proteins (Sutapa Chakrabarti, Christian Freund, Florian Heyd, Alexander Meissner, Markus Wahl, Lydia Herzel, Jana Sticht)
    Schedule: Vorlesung: Freitag, 15:00 - 16:30 h Seminar: Freitag, 16:30 - 17:00 h (Class starts on: 2025-10-17)
    Location: Hs Kristallographie (Takustr. 6)
    

    Information for students

    Further information about blackboard.

    Comments

    Goal: The students possess an extensive understanding of Structural Biochemistry, Molecular Cell Biology and Molecular Biomedicine. They are able to assess research fields and decide on their preferred field of study.
    
    Content: Recent developments in Structural Biochemistry, Molecular Cell Biology and Molecular Biomedicine.
    U.A.:
    

    • Co-transcriptional pre-mRNA processing
    • RNA degradation and quality control
    • Pre-mRNA splicing
    • RNA transport and localization
    • RNA remodeling by helicases
    • Small and long non-coding RNAs
    • Protein folding
    • Protein production in cell-free systems
    • Protein engineering
    • Dynamic aspects of protein structure
    • The role of protein folding in ageing and neuro-degenerative disease
    • Modeling of protein dynamics
    • Protein folding in vitro
    • --> Hydrogen/deuterium exchange
    • --> Fluorescence based methods
    • --> Folding at the ribosome
    • Protein folding and dynamics as described in silico and experimentally by NMR
    • Protein expression
    • Protein folding inside the cell
    • --> Chaperone-assisted folding
    • --> Folding in the ER
    • --> Protein misfolding disease
    
    Prof. Dr. S. Chakrabarti: chakraba@zedat.fu-berlin.de
     Prof. Dr. C. Freund: chfreund@zedat.fu-berlin.de
    Prof. Dr. F. Heyd: florian.heyd@fu-berlin.de
    Prof. Dr. M. Wahl: mwahl@zedat.fu-berlin.de
    Prof. Dr. A. Meissner: office-meissner@molgen.mpg.de
    Dr. J. Sticht: sticht@zedat.fu-berlin.de
    Prof.  Dr. L. Herzel lydia.herzel@fu-berlin.de
    

  • 216101b Seminar
    Advanced Biochemistry - A : Nucleic Acids and Proteins (Sutapa Chakrabarti, Christian Freund, Florian Heyd, Alexander Meissner, Markus Wahl, Lydia Herzel, Jana Sticht)
    Schedule: Vorlesung: Freitag, 15:00 h - 16:30 h , Seminar: Freitag, 16:30 h - 17:00 h (Class starts on: 2025-10-17)
    Location: Hs Kristallographie, Takustr. 6
    

    Information for students

    Further information about blackboard.

    Comments

    Seminar to 216101a Prof. Dr. S. Chakrabarti: chakraba@zedat.fu-berlin.de Prof. Dr. C. Freund: chfreund@zedat.fu-berlin.de Prof. Dr. F. Heyd: florian.heyd@fu-berlin.de Prof. Dr. M. Wahl: mwahl@zedat.fu-berlin.de Prof. Dr. A. Meissner: office-meissner@molgen.mpg.de Dr. J. Sticht: sticht@zedat.fu-berlin.de Prof. Dr. L. Herzel lydia.herzel@fu-berlin.de

• Advanced Biochemistry B - Current Topics in the Biology of Cellular Membranes and Signal Transduction (5 LP)

  0390bA1.2
  • 216101c Lecture
    Advanced Biochemistry - B: Membranes and Signal Transduction (Helge Ewers, Petra Knaus, Francesca Bottanelli, Alexander Meissner)
    Schedule: Vorlesung: Freitag, 15:00 h - 16:30 h , Seminar: Freitag, 16:30 h - 17:00 h (Class starts on: 2025-10-17)
    Location: Hs Biochemie, Thielallee 63 (Lise-Meitner-Hörsaal)
    

    Information for students

    Further information about blackboard.

    Comments

    Qualification goals: Students have up-to-date and structured specialist knowledge in the research fields of membranes and signal transduction. They will be able to assess research directions and determine their future direction of specialization. Content: Current developments in the research fields of membranes and signal transduction. AMONG OTHERS: Kinase Receptor Signaling Extracellular Matrix and Wnt signaling Ion transport and signaling Signaling meets Metabolism Systems Biology of Signaling Cell migration, (cytoskeletal remodeling, biomechanical signaling) Membrane protein synthesis, plasma membrane structure and biophysics Structure and biosynthesis of peripheral membrane proteins Vesicular traffic and endocytosis Molecular mechanisms of protein-mediated membrane curvature and membrane fission Membrane fusion and exocytosis Endomembrane system, ER structure, organelle identity, organelle contact sites
    Prof. Dr. F. Bottanelli: Francesca.bottanelli@fu-berlin.de
    Prof. Dr. H. Ewers: helge.ewers@fu-berlin.de
    Prof. Dr. P. Knaus: knaus@chemie.fu-berlin.de
    Prof. Dr. A. Meissner: office-meissner@molgen.mpg.de
    

  • 216101d Seminar
    Advanced Biochemistry - B: Membranes and Signal Transduction (Helge Ewers, Petra Knaus, N.N., Francesca Bottanelli, Alexander Meissner)
    Schedule: Vorlesung: Freitag, 15:00 h - 16:30 h , Seminar: Freitag, 16:30 h - 17:00 h (Class starts on: 2025-10-17)
    Location: Hs Biochemie, Thielallee 63 (Lise-Meitner-Hörsaal)
    

    Information for students

    Further information about blackboard.

    Comments

    Seminar to 21601c
    
    rof. Dr. F. Bottanelli: Francesca.bottanelli@fu-berlin.de
    Prof. Dr. H. Ewers: helge.ewers@fu-berlin.de
    Prof. Dr. P. Knaus: knaus@chemie.fu-berlin.de
    Prof. Dr. A. Meissner: office-meissner@molgen.mpg.de
    

• Methods in Molecular Biology (5 LP)

  0390bB1.1
  • 216202a Seminar
    Quantitative Fluorescence Microscopy (Helge Ewers, Bas van Bommel)
    Schedule: Block seminar: 19.01. - 30.01.2026; 9:00 h (Class starts on: 2026-01-19)
    Location: Thielallee 63, Seminarraum (Anbau)
    

    Information for students

    This seminar is one part of the methods course "Quantitative Fluorescence Microscopy" and takes place in parallel to the practical course. The seminar can be taken as theoretical module for the area structural biochemistry.

    Comments

    Learning aims: The students will develop an overview of the capabilities of modern light microscopy and a basic understanding of the role of sample preparation and imaging in the formation of quantitative digital data. The students will get insight into the basics of computational image analysis and how data can be extracted from digital image data. The students will learn how to analyze digital images and how to recognize and avoid mistakes in image analysis. Contents: - Fundamentals of fluorescence microscopy - Basics of digital imaging - Fundamental image analysis - Special methods in microscopy - Single molecule microscopy - superresolution microscopy - Fluorescence resonant energy transfer - Machine learning in image analysis Prof. Dr. H. Ewers: helge.ewers@fu-berlin.de Dr. Bas van Bommel: bas.van.bommel@fu-berlin.de

  • 216202b Laboratory Course
    Quantitative Fluorescence Microscopy (Helge Ewers, Bas van Bommel)
    Schedule: Block course: 19.01. - 30.01.2026; all-day (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
    Location: Thielallee 63, Raum 106a (AG Ewers)
    

    Information for students

    Practical part of the methods course "Quantitative Fluorescence Microscopy". The seminar is required to take part in the practical.

    Comments

    Learning aims: The students will generate samples for fluorescence microscopy and acquire images at the confocal and single molecule microscope. They will execute a number of experiments and analyze the acquired data using image J and other software. The students will train a deep-learning model and analyze the data they acquired themselves in superresolution microscopy. The students will critically evaluate the capabilities of modern microscopy techniques from literature research and present them to their peers. Contents: • Live-cell microscopy • Image generation, resolution and point-spread function • Background, Noise, extraktion of quantitative data • Use of Image J • Fluorescence-Recovery after Photobleaching • Single molecule superresolution microscopy • Image analysis with Deep-Learning Prof. Dr. H. Ewers: helge.ewers@fu-berlin.de Dr. Bas van Bommel: bas.van.bommel@fu-berlin.de

  • 216404a Seminar
    Seminar on Bioanalytical Mass Spectrometry / Proteomic Analysis (Benno Kuropka)
    Schedule: block course: 17.11.- 28.11.2025; 9:00 - 10:30 h
    Location: Thielallee 63, Seminarraum (Anbau)
    

    Comments

     

    • Fundamentals of proteome analysis
    • Technical basics of a mass spectrometer
    • Sample preparation and chromatographic peptide separation
    • Ionization methods (ESI and MALDI)
    • Protein identification by MALDI peptide mass fingerprinting
    • Methods for protein analysis (top-down, bottom-up, targeted)
    • Fragmentation methods and interpretation of MS/MS spectra for sequence determination
    • Methods of quantitative proteome analysis including different labeling techniques
    • Identification of protein interactions by affinity-purification MS
    • Analysis of non-covalent protein interactions using native MS
    • Guest Seminars on different topics: e.g. MALDI imaging, crosslinking-MS, carbohydrate analysis, metabolomics
    Dr. Benno Kuropka: kuropka@zedat.fu-berlin.de

  • 216404b Laboratory Course
    Bioanalytical Mass Spectrometry / Proteomic Analysis (Benno Kuropka)
    Schedule: block course 17.11. - 28.11.2025; 10:30h -17:00 h (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
    Location: Thielallee 63, Raum 316 (Labor)
    

    Information for students

    Additional information / Pre-requisites

    Comments

    • Protein identification by MALDI peptide mass fingerprint (PMF) after enzymatic in-gel cleavage.
    • Measurement of intact protein mass by MALDI-MS and sequencing by in source decay (ISD).
    • Quantitative proteome analysis using LC-ESI-MS.
    • High-resolution measurement of intact proteins under denaturing and native conditions (Orbitrap ESI-MS).

     

     

    Dr. Benno Kuropka: kuropka@zedat.fu-berlin.de

  • 216405a Seminar
    Mechanisms of Alternative Splicing Regulation (Florian Heyd, Marco Preußner)
    Schedule: block seminar: 19.01.26 - 30.01.26; begin: 19.01.26, 9:00 h, The exact schedule will be announced during the first course day.
    Location: Takustr. 6, room 003 (seminar room)
    

    Information for students

    Das Seminar findet parallel zum Praktikum statt.

    Comments

    Content:
    

    • RNA world model
    • Properties of nucleic acids
    • Chemical synthesis of DNA and RNA
    • Purification of oligonucleotides
    • Chemical synthesis of modified nucleic acids
    • Structural analysis of nucleic acids
    • Small and large ribozymes
    • Noncoding RNAs
    • Antisense strategies and RNA interference
    • Design of aptamers and spiegelmers
    • Biochip developments with nucleic acids
    • Biosensors employing nucleic acids
    • Nucleic acids as novel diagnostics
    • Clinical developments with nucleic acid drugs
    • Abzymes and aptazymes
    • Protein design through display strategies
    
    Prof. Dr. F. Heyd: florian.heyd@fu-berlin.de Dr. Marco Preußner: mpreussner@zedat.fu-berlin.de

  • 216405b Laboratory Course
    Mechanisms of Alternative Splicing Regulation (Florian Heyd, Marco Preußner)
    Schedule: block seminar and practical course: 19.01.26 - 30.01.26, all day, (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
    Location: Takustr. 6, room 001-002 (laboratory)
    

    Information for students

    Die Teilnahme am Seminar ist Voraussetzung für die Teilnahme am Praktikum.

    Comments

    Content:

    • Safe handling of radioisotopes
    • Chemical synthesis of oligonucleotides
    • Purification of oligonucleotides via HPLC
    • Purification of oligonucleotides via PAGE
    • Radioactive Labeling of oligonucleotides
    • Single-turnover kinetics on hammerhead ribozymes
    • Purification of target proteins
    • Synthesis of a combinatorial RNA library
    • Enrichment of oligoribonucleotides binding to a target
    • cDNA synthesis via reverse transcription
    • PCR amplification
    
    Prof. Dr. F. Heyd: florian.heyd@fu-berlin.de Dr. Marco Preußner: mpreussner@zedat.fu-berlin.de

  • 216406a Seminar
    Gene editing with CRISPR/Cas9 for cell biology (Francesca Bottanelli)
    Schedule: block course 02.02. - 13.02.26; 09:00-10:00 h The exact schedule will be announced during the seminar.
    Location: Thielallee 63, Raum 321 (AG Bottanelli)
    

    Information for students

    The seminar is limited to 10 students. Please register via mail to: bottanelli@zedat.fu-berlin.de until 19.12.2025.

    Comments

    Content:
    The students will learn:
    • How to use bio-informatic tools for CRISPR/Cas9 technology
    • How to clone all the required plasmids for the insertion of tags into the genomic locus of genes of interest
    • How to culture and transfect human cell culture models
    
    Prof. Dr. Bottanelli: Francesca.bottanelli@fu-berlin.de

  • 216406b Laboratory Course
    Gene editing with CRISPR/Cas9 for cell biology (Francesca Bottanelli)
    Schedule: block course 02.02. - 13.02.26; 09:00 h, all day (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
    Location: Thielallee 63, Rauminformation über Blackboard (AG Bottanelli)
    

    Comments

    Content:
    The students will learn:
    • How to use bio-informatic tools for CRISPR/Cas9 technology
    • How to clone all the required plasmids for the insertion of tags into the genomic locus of genes of interest
    • How to culture and transfect human cell culture models
    
    Prof. Dr. Bottanelli: Francesca.bottanelli@fu-berlin.de

  • 216601a Seminar
    Cell biology (advanced course): Signal transduction (Petra Knaus)
    Schedule: Seminar: 09.03. - 20.03.26 , 1st week: Mo. 9:00-11:00 am, Tue.-Thu. 10:00 - 11:30 am 2nd week: Thu. 9:00 am - 06:00 pm, Fri. 9:00 am - 01:00 pm
    Location: Thielallee 63, room 221 (Knaus group) and Onlinelehre – zeitABhängig.
    

    Information for students

    Attention: changes in timetable are possible, after enrollment for the course you will be informed via e-mail

    Comments

    Seminar content:
    

    • The current view on BMP and TGFß signal transduction beyond the fundamental knowledge (intracellular and extracellular modulators, the importance of intensity and kinetics as well as subcellular localization of effector proteins, crosstalk mechanisms between related pathways).
    • Step-by-Step experimental outline and rational to address each individual step of signal transduction starting with ligand binding to the receptors, receptor activation and intracellular activation and shuttling of SMAD transcription factors binding to the DNA upon nuclear import.
    • How to investigate the different steps of signal transduction by complementary methods.
    • Paper discussion (presented by the students) focusing on recent papers that have been influential in the current view on BMP and TGFß signal transduction.
    • Intense practical and theoretical supervision due to the limited number of participants.
    
    
    Prof. Dr. P. Knaus: knaus@chemie.fu-berlin.de
    

  • 216601b Laboratory Course
    Cell biology (advanced course): Signal transduction (Petra Knaus)
    Schedule: block course: 09.03. - 20.03.26, with seminars; (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
    Location: Thielallee 63, Raum 001 and 004/005 (Labore)
    

    Comments

    Practical content:
    

    • Studying BMP/TGFß- induced signal transduction on multiple levels of the signaling cascade
    • Use of biochemical assays which allow to analyze BMP/TGFß signal transduction in a quantitative manner (qRT-PCR, quantitative Western-Blotting)
    • Use of biochemical assays which allow for analysis of BMP/TGFß signal transduction in a kinetic manner. Ligand stimulation, transcription factor translocation events, use of Luciferase-based reporter gene assay, activation of BMP-SMAD target genes
    • Use of biochemical assays which allow to analyze BMP/TGFß signal transduction with spatial resolution, subcellular localization of transcription factors using fluorescence microscopy
    • Using tools/strategies to artificially manipulate signal transduction (small molecule inhibitors targeting receptor-kinase activity, overexpression of tagged proteins of the BMP signal transduction cascade by transient-transfection methodology of overexpression plasmids.
    • Extensive discussion on experimental design, drawbacks and pitfalls when designing an experiment to investigate signal transduction.
    • Extensive discussions on appropriate controls to be implemented into the experimental design.
    • Summary of the experimental results by simulating how to write a primary research paper.
    
    
    Prof. Dr. P. Knaus: knaus@chemie.fu-berlin.de
    

  • 216602a Seminar
    Molecular Immunology (Christian Freund, Jana Sticht)
    Schedule: block course: 03.11.-14.11.25 (Class starts on: 2025-11-03)
    Location: Thielallee 63, Seminarraum (Anbau)
    

    Information for students

    The seminars are limited to 4 students in addition to the 6 students participating in the practical course 216602b. Please enrol via Email to: chfreund@zedat.fu-berlin.de AND sticht@zedat.fu-berlin.de
    until 15th Oktober 2025.

    Comments

    Inhalt/Content:
    

    - Introduction to Immunology: Innate and adaptive immune responses

    - The adaptive immune system: B and T cells

    - The adaptive immune system: antigen presentation by MHC molecules

    - Investigating MHC-peptide complexes by NMR spectroscopy

    - Immunopeptidomics (Mass spectrometry analysis of peptide presentation)

    - PyMol to visualize and analyze protein structures
    
    Prof. Dr. C. Freund: chfreund@zedat.fu-berlin.de
    Dr. J. Sticht: sticht@zedat.fu-berlin.de

  • 216602b Laboratory Course
    Molecular Immunology (Christian Freund, Jana Sticht)
    Schedule: block course: 03.11.-14.11.25 (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
    Location: Thielallee 63, Raum 016/018 und 025/027 (AG Freund)
    

    Comments

    Content:
    

    - MHC-peptide exchange experiments
    - Measuring the stability of MHC-peptide complexes
    - NMR of MHC-peptide complexes
    - Visualization of mutations and mapped epitopes in PyMol
    - Immunopeptidomics I - Affinity purification
    - Immunopeptidomics II - MS analysis and epitope prediction for T cell antigens
    
    Prof. Dr. C. Freund: chfreund@zedat.fu-berlin.de
    Dr. J. Sticht: sticht@zedat.fu-berlin.de

  • 216613a Seminar
    Molecular Pharmacology and Cellular Signal Transduction (Ralf Schülein, Volker Haucke)
    Schedule: block seminar and practical course S/P: 16.03. - 27.03.26, 9:00 - 17:00 h; Seminar Di - Fr 9:00 - 10:30 h
    Location: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) , Robert-Rössle-Str. 10, 13125 Berlin Buch
    

    Information for students

    Seminar is included in the 2 week practical course

    Comments

    Exemplary seminar content:
    

    • Mechanoreception
    • Epigenetic mechanisms downstream of Wnt/beta-catenin in carcinomas and cancer stem cells
    • CIC chloride channels and transporters: insights from knockout mice and inherited diseases
    • G protein-coupled receptors and effector systems
    • Identification of novel drugs using high throughput screening
    • Ligand-gated ion channels
    • Neurotransmitter release and vesicle recycling
    • Protein conjugates
    
    
    Prof. Dr. R. Schülein: schuelein@fmp-berlin.de

  • 216613b Laboratory Course
    Molecular Pharmacology and Cellular Signal Transduction (Ralf Schülein, Volker Haucke)
    Schedule: block seminar and practical course S/P: 16.03. - 27.03.26, 9:00 - 17:00 h; Seminar Di - Fr 9:00 - 10:30 h (Tombola – Attention: the distribution mode has been changed. Please refer to the notice at the beginning of the course catalog.)
    Location: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) , Robert-Rössle-Str. 10, 13125 Berlin Buch
    

    Information for students

    Practical course with integrated seminar.

    Comments

    Practical content:
    

    • TIRF microscopy
    • Molecular modelling
    • Signaling by inositol pyrophosphates
    • Mass spectrometry and proteomics
    • Transgenic animals
    • Proteostasis in C. elegans
    • Voltage clamp
    • NMR spectroscopy
    
    
    Prof. Dr. R. Schülein: schuelein@fmp-berlin.de
    • 216641b Seminar
      Self-replicating protein particles and neurodegeneration in Alzheimer´s disease, Parkinson´s disease and prion diseases (Michael Beekes)
      Schedule: block course (schedule will be announced during the lecture 216641a)
      Location: Robert Koch Institute; Nordufer 20, 13353 Berlin, building 1
      

      Information for students

      The seminar can only be attended in combination with the practical course 216641 c!

      Additional information / Pre-requisites

      Attention: Slots will be distributed by the lecturer during course 216641a in a prior semester.
      The seminar takes place within the practical course.

      Comments

      Recapitulation of key points from seminar 216641a with a focus on the topics of lab course 21661c
      Preparatory discussion of the experiments of lab course 216641c
      Oral presentations by the students on selected publications related to the experiments of lab course 216641c
      
      PD Dr. M. Beekes: BeekesM@rki.de

    • 216641c Laboratory Course
      Self-replicating protein particles and neurodegeneration in Alzheimer´s disease, Parkinson´s disease and prion diseases (Michael Beekes)
      Schedule: 2-week block practical (schedule will be announced during the lecture 216641a) Enrollment for this module will by the instructor
      Location: Robert Koch Institute; Nordufer 20, 13353 Berlin, building 1
      

      Information for students

      Practical course with seminar. Prerequisite: Attendance of lecture 216641a. Slots will be distributed by the lecturer to selected students, which already successfully attended the lecture in a prior semester.

      Additional information / Pre-requisites

      Briefing: The briefing will take place during the lecture 216641 a in the summer semester 2019

      Comments

      Content:
      

      • Preparation of paraffin-embedded brain sections for histological and immunohistochemical analyses
      • Immunohistochemical detection of Parkinson-associated aggregated alpha-synuclein in brain sections
      • Immunohistochemical detection of glial fibrillary acid protein as a marker for astrocytes in brain sections
      • Immunohistochemical detection of neuron-specific nuclear protein as a marker for neurons in brain sections
      • Immunohistochemical detection of dopaminergic neurons in brain sections
      • Haematoxylin eosin staining of brain sections for visualisation of vacuolar prion pathology
      • Detection of infectious prion protein (PrPSc) in Proteinase K - digested brain sections on nitrocellulose membranes by the paraffin-embedded tissue (PET) blot technique
      • Western blot detection of Alzheimer-associated aggregated amyloid-beta (Aß) and tau protein from brain tissue
      • Extraction, purification and Western blot detection of infectious prion protein (PrPSc) from prion-infected muscle tissue
      • In vitro analysis of the chemical destabilisation and degradation of infectious prion protein (PrPSc)
      • Cell-free protein misfolding cyclic amplification (PMCA) of infectious prion proteins
      
      
      PD Dr. M. Beekes: BeekesM@rki.de

    • Methods module (10 LP)

      0390bB1.11
      • 216201a Seminar
        Biomolecular X-Ray Crystallography (Markus Wahl; Berhard Loll)
        Schedule: 17.11. - 28.11.25 Mo, Mi, Fr - 9-:00 - 11:00 Uhr and concluding seminar on 12.12.25
        Location: Takustr. 6, room 323 (Wahl group)
        

        Information for students

        Part of the method module "Grundlagen der Strukturbiochemie". It is possible to attend this module-part as a theoretical module in the field of structural biochemistry.

        Comments

        Method module: Fundamentals of Structural Biochemistry 
        University/Department/Institute: Freie Universität Berlin/Department of Biology, Chemistry, Pharmacy/Institute of Chemistry and Biochemistry 
        Person responsible for the module: Lecturers of the module 
        Admission requirements: none 
        
        Qualification goals: Students learn methods for the preparation of biological macromolecules and for structural analysis. They acquire the theoretical basics of macromolecular structural analysis methods. Students are able to assess macromolecular properties that play a role in structural analysis. They will be able to critically evaluate manuscripts in which macromolecular structures and structural analyses are described and assess the quality of macromolecular structures. Contents: Preparation of a sample of a biological macromolecule for structural analysis; bioinformatic, biochemical or biophysical characterization of a biological macromolecule; performance of one or more procedures for structural analysis; structural description and graphical representation of structures; presentation of structural biology experiments and results. 
        Content of the seminar: 
        
        Protein production and characterization 
        Protein crystallization and protein crystals 
        Crystallographic symmetry 
        X-ray diffraction theory 
        The phase problem and phasing strategies 
        Electron density, model building, refinement, validation 
        
        

      • 216201b Seminar
        Advanced X-Ray Crystallography (Oliver Daumke, Bernhard Loll, Gert Weber, Manfred Weiss)
        Schedule: see additional information 01.12. - 05.12.25 and 08.12. - 11.12.25, Mo, Mi, Fr - 9:00 - 11:00 Uhr and concluding seminar on 12.12.25
        Location: see additional information
        

        Information for students

        Teilmodul des Methodenkurses "Grundlagen der Strukturbiochemie"

        Additional information / Pre-requisites

        The course will take place at the HZB/Bessy from 01.12. -05.12.2025 and at the MDC from 08.12. - 11.12.25 and  concluding seminar on 12.12.25 (Takustr. 6, Room 323, Wahl group)
        
        The exact dates and places (HZB/BESSY and MDC) upon request (both are planned individual from each group and are dependant on the process of the experiments).
        
        

        Comments

        Method module: Fundamentals of Structural Biochemistry 
        University/Department/Institute: Freie Universität Berlin/Department of Biology, Chemistry, Pharmacy/Institute of Chemistry and Biochemistry 
        Person responsible for the module: Lecturers of the module 
        Admission requirements: none 
        
        Qualification goals: Students learn methods for the preparation of biological macromolecules and for structural analysis. They acquire the theoretical basics of macromolecular structural analysis methods. Students are able to assess macromolecular properties that play a role in structural analysis. They will be able to critically evaluate manuscripts in which macromolecular structures and structural analyses are described and assess the quality of macromolecular structures. Contents: Preparation of a sample of a biological macromolecule for structural analysis; bioinformatic, biochemical or biophysical characterization of a biological macromolecule; performance of one or more procedures for structural analysis; structural description and graphical representation of structures; presentation of structural biology experiments and results. 
        Content of the seminar: 
        
        Protein production and characterization 
        Protein crystallization and protein crystals 
        Crystallographic symmetry 
        X-ray diffraction theory 
        The phase problem and phasing strategies 
        Electron density, model building, refinement, validation 
        

      • 216201c Laboratory Course
        Biomolecular X-Ray Crystallography (Oliver Daumke, Bernhard Loll, Markus Wahl, Gert Weber, Manfred Weiss)
        Schedule: see additional information 17.11. - 28.11.2025 and 01.12. - 05.12.2025 and 08.12 - 11.12.2025 (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
        Location: see additional information
        

        Information for students

        Teilmodul des Methodenkurses "Grundlagen der Strukturbiochemie"

        Additional information / Pre-requisites

        Additional informations:
        
        Part 1: Wahl, Loll
        Schedule:.17.11 - 28.11.2025
        Location: Takustr. 6, 3. OG, Wahl group
        
        Part 2: Weiss Important note: Pregnant and breastfeeding women are prohibited from working on the storage ring (Part 2) due to radiation protection regulations.
        Schedule: 01.12. - 05.12.2025, Meeting point at 10:00 am at the gatekeeper
        Location: c/o Soft Matter and Functional Materials, Elektronenspeicherring BESSY II, Albert-Einstein-Str. 15, 12489 Berlin, Adlershof
        
        Part 3: Daumke
        Schedule: 08.12. - 11.12..2025
        Location: MDC für Molekulare Medizin, Robert-Rössle-Str. 10. 13125 Berlin (Buch), Seminar: MDC.C (Haus 83). Dendrit 2; Praktikum: Haus 31.2, Raum 0248 (AG Heinemann) (s.Vorlesungsverzeichnis)
        
        

        Comments

        Method module: Fundamentals of Structural Biochemistry 
        University/Department/Institute: Freie Universität Berlin/Department of Biology, Chemistry, Pharmacy/Institute of Chemistry and Biochemistry 
        Person responsible for the module: Lecturers of the module 
        Admission requirements: none 
        
        Qualification goals: Students learn methods for the preparation of biological macromolecules and for structural analysis. They acquire the theoretical basics of macromolecular structural analysis methods. Students are able to assess macromolecular properties that play a role in structural analysis. They will be able to critically evaluate manuscripts in which macromolecular structures and structural analyses are described and assess the quality of macromolecular structures. Contents: Preparation of a sample of a biological macromolecule for structural analysis; bioinformatic, biochemical or biophysical characterization of a biological macromolecule; performance of one or more procedures for structural analysis; structural description and graphical representation of structures; presentation of structural biology experiments and results. 
        Content of the seminar: 
        
        Protein production and characterization 
        Protein crystallization and protein crystals 
        Crystallographic symmetry 
        X-ray diffraction theory 
        The phase problem and phasing strategies 
        Electron density, model building, refinement, validation 
        
        

    • Methods in Structural Biology and Biophysics (5 LP)

      0390bB1.2
      • 216202a Seminar
        Quantitative Fluorescence Microscopy (Helge Ewers, Bas van Bommel)
        Schedule: Block seminar: 19.01. - 30.01.2026; 9:00 h (Class starts on: 2026-01-19)
        Location: Thielallee 63, Seminarraum (Anbau)
        

        Information for students

        This seminar is one part of the methods course "Quantitative Fluorescence Microscopy" and takes place in parallel to the practical course. The seminar can be taken as theoretical module for the area structural biochemistry.

        Comments

        Learning aims: The students will develop an overview of the capabilities of modern light microscopy and a basic understanding of the role of sample preparation and imaging in the formation of quantitative digital data. The students will get insight into the basics of computational image analysis and how data can be extracted from digital image data. The students will learn how to analyze digital images and how to recognize and avoid mistakes in image analysis. Contents: - Fundamentals of fluorescence microscopy - Basics of digital imaging - Fundamental image analysis - Special methods in microscopy - Single molecule microscopy - superresolution microscopy - Fluorescence resonant energy transfer - Machine learning in image analysis Prof. Dr. H. Ewers: helge.ewers@fu-berlin.de Dr. Bas van Bommel: bas.van.bommel@fu-berlin.de

      • 216202b Laboratory Course
        Quantitative Fluorescence Microscopy (Helge Ewers, Bas van Bommel)
        Schedule: Block course: 19.01. - 30.01.2026; all-day (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
        Location: Thielallee 63, Raum 106a (AG Ewers)
        

        Information for students

        Practical part of the methods course "Quantitative Fluorescence Microscopy". The seminar is required to take part in the practical.

        Comments

        Learning aims: The students will generate samples for fluorescence microscopy and acquire images at the confocal and single molecule microscope. They will execute a number of experiments and analyze the acquired data using image J and other software. The students will train a deep-learning model and analyze the data they acquired themselves in superresolution microscopy. The students will critically evaluate the capabilities of modern microscopy techniques from literature research and present them to their peers. Contents: • Live-cell microscopy • Image generation, resolution and point-spread function • Background, Noise, extraktion of quantitative data • Use of Image J • Fluorescence-Recovery after Photobleaching • Single molecule superresolution microscopy • Image analysis with Deep-Learning Prof. Dr. H. Ewers: helge.ewers@fu-berlin.de Dr. Bas van Bommel: bas.van.bommel@fu-berlin.de

      • 216302a Seminar
        Structural Ananlysis of Supramolecular Architechtures and Proteins with Electron Microscopy Methods (Kai Ludwig, Tarek Hilal)
        Schedule: Block course 09.02. – 20.02.26 (9:00 - 18:00 h);
        Location: Fabeckstr. 36a, room 205 (Research Center of Electron Microscopy)
        

        Comments

        The block course is aimed at students with an interest in research-relevant questions of structure elucidation on synthetic supramolecular architectures as well as biological macromolecules and introduces in particular transmission electron microscopy (TEM) in cryo mode. In the first part, questions of preparation, in particular cryofixation, basics of equipment design and function, imaging and evaluation, principles of digital image processing, and handling of transmission electron microscopes are covered theoretically and practically. The second part covers theoretical and practical aspects of modern structure elucidation by means of single particle analysis and enables the students to understand the formation of a high-resolution 3D reconstruction of a protein structure.
        
        Dr. Kai Ludwig: kai.ludwig@fzem.fu-berlin.de
        Dr. Tarek Hilal: tarek.hilal@fzem.fu-berlin.de

      • 216302b Laboratory Course
        Structural Ananlysis of Supramolecular Architechtures and Proteins with Electron Microscopy Methods (Kai Ludwig, Tarek Hilal)
        Schedule: Block course 09.02. – 20.02.26 (9:00 - 18:00 h); (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
        Location: Fabeckstr. 36a, room 205 (Research Center of Electron Microscopy)
        

        Comments

        The block course is aimed at students with an interest in research-relevant questions of structure elucidation on synthetic supramolecular architectures as well as biological macromolecules and introduces in particular transmission electron microscopy (TEM) in cryo mode. In the first part, questions of preparation, in particular cryofixation, basics of equipment design and function, imaging and evaluation, principles of digital image processing, and handling of transmission electron microscopes are covered theoretically and practically. The second part covers theoretical and practical aspects of modern structure elucidation by means of single particle analysis and enables the students to understand the formation of a high-resolution 3D reconstruction of a protein structure.
        
        Dr. Kai Ludwig: kai.ludwig@fzem.fu-berlin.de
        Dr. Tarek Hilal: tarek.hilal@fzem.fu-berlin.de

      • 216404a Seminar
        Seminar on Bioanalytical Mass Spectrometry / Proteomic Analysis (Benno Kuropka)
        Schedule: block course: 17.11.- 28.11.2025; 9:00 - 10:30 h
        Location: Thielallee 63, Seminarraum (Anbau)
        

        Comments

         

        • Fundamentals of proteome analysis
        • Technical basics of a mass spectrometer
        • Sample preparation and chromatographic peptide separation
        • Ionization methods (ESI and MALDI)
        • Protein identification by MALDI peptide mass fingerprinting
        • Methods for protein analysis (top-down, bottom-up, targeted)
        • Fragmentation methods and interpretation of MS/MS spectra for sequence determination
        • Methods of quantitative proteome analysis including different labeling techniques
        • Identification of protein interactions by affinity-purification MS
        • Analysis of non-covalent protein interactions using native MS
        • Guest Seminars on different topics: e.g. MALDI imaging, crosslinking-MS, carbohydrate analysis, metabolomics
        Dr. Benno Kuropka: kuropka@zedat.fu-berlin.de

      • 216404b Laboratory Course
        Bioanalytical Mass Spectrometry / Proteomic Analysis (Benno Kuropka)
        Schedule: block course 17.11. - 28.11.2025; 10:30h -17:00 h (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
        Location: Thielallee 63, Raum 316 (Labor)
        

        Information for students

        Additional information / Pre-requisites

        Comments

        • Protein identification by MALDI peptide mass fingerprint (PMF) after enzymatic in-gel cleavage.
        • Measurement of intact protein mass by MALDI-MS and sequencing by in source decay (ISD).
        • Quantitative proteome analysis using LC-ESI-MS.
        • High-resolution measurement of intact proteins under denaturing and native conditions (Orbitrap ESI-MS).

         

         

        Dr. Benno Kuropka: kuropka@zedat.fu-berlin.de

      • 216406b Laboratory Course
        Gene editing with CRISPR/Cas9 for cell biology (Francesca Bottanelli)
        Schedule: block course 02.02. - 13.02.26; 09:00 h, all day (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
        Location: Thielallee 63, Rauminformation über Blackboard (AG Bottanelli)
        

        Comments

        Content:
        The students will learn:
        • How to use bio-informatic tools for CRISPR/Cas9 technology
        • How to clone all the required plasmids for the insertion of tags into the genomic locus of genes of interest
        • How to culture and transfect human cell culture models
        
        Prof. Dr. Bottanelli: Francesca.bottanelli@fu-berlin.de

      • 216601b Laboratory Course
        Cell biology (advanced course): Signal transduction (Petra Knaus)
        Schedule: block course: 09.03. - 20.03.26, with seminars; (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
        Location: Thielallee 63, Raum 001 and 004/005 (Labore)
        

        Comments

        Practical content:
        

        • Studying BMP/TGFß- induced signal transduction on multiple levels of the signaling cascade
        • Use of biochemical assays which allow to analyze BMP/TGFß signal transduction in a quantitative manner (qRT-PCR, quantitative Western-Blotting)
        • Use of biochemical assays which allow for analysis of BMP/TGFß signal transduction in a kinetic manner. Ligand stimulation, transcription factor translocation events, use of Luciferase-based reporter gene assay, activation of BMP-SMAD target genes
        • Use of biochemical assays which allow to analyze BMP/TGFß signal transduction with spatial resolution, subcellular localization of transcription factors using fluorescence microscopy
        • Using tools/strategies to artificially manipulate signal transduction (small molecule inhibitors targeting receptor-kinase activity, overexpression of tagged proteins of the BMP signal transduction cascade by transient-transfection methodology of overexpression plasmids.
        • Extensive discussion on experimental design, drawbacks and pitfalls when designing an experiment to investigate signal transduction.
        • Extensive discussions on appropriate controls to be implemented into the experimental design.
        • Summary of the experimental results by simulating how to write a primary research paper.
        
        
        Prof. Dr. P. Knaus: knaus@chemie.fu-berlin.de
        

      • 216602a Seminar
        Molecular Immunology (Christian Freund, Jana Sticht)
        Schedule: block course: 03.11.-14.11.25 (Class starts on: 2025-11-03)
        Location: Thielallee 63, Seminarraum (Anbau)
        

        Information for students

        The seminars are limited to 4 students in addition to the 6 students participating in the practical course 216602b. Please enrol via Email to: chfreund@zedat.fu-berlin.de AND sticht@zedat.fu-berlin.de
        until 15th Oktober 2025.

        Comments

        Inhalt/Content:
        

        - Introduction to Immunology: Innate and adaptive immune responses

        - The adaptive immune system: B and T cells

        - The adaptive immune system: antigen presentation by MHC molecules

        - Investigating MHC-peptide complexes by NMR spectroscopy

        - Immunopeptidomics (Mass spectrometry analysis of peptide presentation)

        - PyMol to visualize and analyze protein structures
        
        Prof. Dr. C. Freund: chfreund@zedat.fu-berlin.de
        Dr. J. Sticht: sticht@zedat.fu-berlin.de

      • 216602b Laboratory Course
        Molecular Immunology (Christian Freund, Jana Sticht)
        Schedule: block course: 03.11.-14.11.25 (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
        Location: Thielallee 63, Raum 016/018 und 025/027 (AG Freund)
        

        Comments

        Content:
        

        - MHC-peptide exchange experiments
        - Measuring the stability of MHC-peptide complexes
        - NMR of MHC-peptide complexes
        - Visualization of mutations and mapped epitopes in PyMol
        - Immunopeptidomics I - Affinity purification
        - Immunopeptidomics II - MS analysis and epitope prediction for T cell antigens
        
        Prof. Dr. C. Freund: chfreund@zedat.fu-berlin.de
        Dr. J. Sticht: sticht@zedat.fu-berlin.de

      • 216613a Seminar
        Molecular Pharmacology and Cellular Signal Transduction (Ralf Schülein, Volker Haucke)
        Schedule: block seminar and practical course S/P: 16.03. - 27.03.26, 9:00 - 17:00 h; Seminar Di - Fr 9:00 - 10:30 h
        Location: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) , Robert-Rössle-Str. 10, 13125 Berlin Buch
        

        Information for students

        Seminar is included in the 2 week practical course

        Comments

        Exemplary seminar content:
        

        • Mechanoreception
        • Epigenetic mechanisms downstream of Wnt/beta-catenin in carcinomas and cancer stem cells
        • CIC chloride channels and transporters: insights from knockout mice and inherited diseases
        • G protein-coupled receptors and effector systems
        • Identification of novel drugs using high throughput screening
        • Ligand-gated ion channels
        • Neurotransmitter release and vesicle recycling
        • Protein conjugates
        
        
        Prof. Dr. R. Schülein: schuelein@fmp-berlin.de

      • 216613b Laboratory Course
        Molecular Pharmacology and Cellular Signal Transduction (Ralf Schülein, Volker Haucke)
        Schedule: block seminar and practical course S/P: 16.03. - 27.03.26, 9:00 - 17:00 h; Seminar Di - Fr 9:00 - 10:30 h (Tombola – Attention: the distribution mode has been changed. Please refer to the notice at the beginning of the course catalog.)
        Location: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) , Robert-Rössle-Str. 10, 13125 Berlin Buch
        

        Information for students

        Practical course with integrated seminar.

        Comments

        Practical content:
        

        • TIRF microscopy
        • Molecular modelling
        • Signaling by inositol pyrophosphates
        • Mass spectrometry and proteomics
        • Transgenic animals
        • Proteostasis in C. elegans
        • Voltage clamp
        • NMR spectroscopy
        
        
        Prof. Dr. R. Schülein: schuelein@fmp-berlin.de

        • Methods in Molecular Biology, Structural Biology and Biophysics (10 LP)

          0390bB1.3
          • 216201a Seminar
            Biomolecular X-Ray Crystallography (Markus Wahl; Berhard Loll)
            Schedule: 17.11. - 28.11.25 Mo, Mi, Fr - 9-:00 - 11:00 Uhr and concluding seminar on 12.12.25
            Location: Takustr. 6, room 323 (Wahl group)
            

            Information for students

            Part of the method module "Grundlagen der Strukturbiochemie". It is possible to attend this module-part as a theoretical module in the field of structural biochemistry.

            Comments

            Method module: Fundamentals of Structural Biochemistry 
            University/Department/Institute: Freie Universität Berlin/Department of Biology, Chemistry, Pharmacy/Institute of Chemistry and Biochemistry 
            Person responsible for the module: Lecturers of the module 
            Admission requirements: none 
            
            Qualification goals: Students learn methods for the preparation of biological macromolecules and for structural analysis. They acquire the theoretical basics of macromolecular structural analysis methods. Students are able to assess macromolecular properties that play a role in structural analysis. They will be able to critically evaluate manuscripts in which macromolecular structures and structural analyses are described and assess the quality of macromolecular structures. Contents: Preparation of a sample of a biological macromolecule for structural analysis; bioinformatic, biochemical or biophysical characterization of a biological macromolecule; performance of one or more procedures for structural analysis; structural description and graphical representation of structures; presentation of structural biology experiments and results. 
            Content of the seminar: 
            
            Protein production and characterization 
            Protein crystallization and protein crystals 
            Crystallographic symmetry 
            X-ray diffraction theory 
            The phase problem and phasing strategies 
            Electron density, model building, refinement, validation 
            
            

          • 216201b Seminar
            Advanced X-Ray Crystallography (Oliver Daumke, Bernhard Loll, Gert Weber, Manfred Weiss)
            Schedule: see additional information 01.12. - 05.12.25 and 08.12. - 11.12.25, Mo, Mi, Fr - 9:00 - 11:00 Uhr and concluding seminar on 12.12.25
            Location: see additional information
            

            Information for students

            Teilmodul des Methodenkurses "Grundlagen der Strukturbiochemie"

            Additional information / Pre-requisites

            The course will take place at the HZB/Bessy from 01.12. -05.12.2025 and at the MDC from 08.12. - 11.12.25 and  concluding seminar on 12.12.25 (Takustr. 6, Room 323, Wahl group)
            
            The exact dates and places (HZB/BESSY and MDC) upon request (both are planned individual from each group and are dependant on the process of the experiments).
            
            

            Comments

            Method module: Fundamentals of Structural Biochemistry 
            University/Department/Institute: Freie Universität Berlin/Department of Biology, Chemistry, Pharmacy/Institute of Chemistry and Biochemistry 
            Person responsible for the module: Lecturers of the module 
            Admission requirements: none 
            
            Qualification goals: Students learn methods for the preparation of biological macromolecules and for structural analysis. They acquire the theoretical basics of macromolecular structural analysis methods. Students are able to assess macromolecular properties that play a role in structural analysis. They will be able to critically evaluate manuscripts in which macromolecular structures and structural analyses are described and assess the quality of macromolecular structures. Contents: Preparation of a sample of a biological macromolecule for structural analysis; bioinformatic, biochemical or biophysical characterization of a biological macromolecule; performance of one or more procedures for structural analysis; structural description and graphical representation of structures; presentation of structural biology experiments and results. 
            Content of the seminar: 
            
            Protein production and characterization 
            Protein crystallization and protein crystals 
            Crystallographic symmetry 
            X-ray diffraction theory 
            The phase problem and phasing strategies 
            Electron density, model building, refinement, validation 
            

          • 216201c Laboratory Course
            Biomolecular X-Ray Crystallography (Oliver Daumke, Bernhard Loll, Markus Wahl, Gert Weber, Manfred Weiss)
            Schedule: see additional information 17.11. - 28.11.2025 and 01.12. - 05.12.2025 and 08.12 - 11.12.2025 (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
            Location: see additional information
            

            Information for students

            Teilmodul des Methodenkurses "Grundlagen der Strukturbiochemie"

            Additional information / Pre-requisites

            Additional informations:
            
            Part 1: Wahl, Loll
            Schedule:.17.11 - 28.11.2025
            Location: Takustr. 6, 3. OG, Wahl group
            
            Part 2: Weiss Important note: Pregnant and breastfeeding women are prohibited from working on the storage ring (Part 2) due to radiation protection regulations.
            Schedule: 01.12. - 05.12.2025, Meeting point at 10:00 am at the gatekeeper
            Location: c/o Soft Matter and Functional Materials, Elektronenspeicherring BESSY II, Albert-Einstein-Str. 15, 12489 Berlin, Adlershof
            
            Part 3: Daumke
            Schedule: 08.12. - 11.12..2025
            Location: MDC für Molekulare Medizin, Robert-Rössle-Str. 10. 13125 Berlin (Buch), Seminar: MDC.C (Haus 83). Dendrit 2; Praktikum: Haus 31.2, Raum 0248 (AG Heinemann) (s.Vorlesungsverzeichnis)
            
            

            Comments

            Method module: Fundamentals of Structural Biochemistry 
            University/Department/Institute: Freie Universität Berlin/Department of Biology, Chemistry, Pharmacy/Institute of Chemistry and Biochemistry 
            Person responsible for the module: Lecturers of the module 
            Admission requirements: none 
            
            Qualification goals: Students learn methods for the preparation of biological macromolecules and for structural analysis. They acquire the theoretical basics of macromolecular structural analysis methods. Students are able to assess macromolecular properties that play a role in structural analysis. They will be able to critically evaluate manuscripts in which macromolecular structures and structural analyses are described and assess the quality of macromolecular structures. Contents: Preparation of a sample of a biological macromolecule for structural analysis; bioinformatic, biochemical or biophysical characterization of a biological macromolecule; performance of one or more procedures for structural analysis; structural description and graphical representation of structures; presentation of structural biology experiments and results. 
            Content of the seminar: 
            
            Protein production and characterization 
            Protein crystallization and protein crystals 
            Crystallographic symmetry 
            X-ray diffraction theory 
            The phase problem and phasing strategies 
            Electron density, model building, refinement, validation 
            
            

        • Methods in Molecular Genetics (5 LP)

          0390bB1.4
          • 216406a Seminar
            Gene editing with CRISPR/Cas9 for cell biology (Francesca Bottanelli)
            Schedule: block course 02.02. - 13.02.26; 09:00-10:00 h The exact schedule will be announced during the seminar.
            Location: Thielallee 63, Raum 321 (AG Bottanelli)
            

            Information for students

            The seminar is limited to 10 students. Please register via mail to: bottanelli@zedat.fu-berlin.de until 19.12.2025.

            Comments

            Content:
            The students will learn:
            • How to use bio-informatic tools for CRISPR/Cas9 technology
            • How to clone all the required plasmids for the insertion of tags into the genomic locus of genes of interest
            • How to culture and transfect human cell culture models
            
            Prof. Dr. Bottanelli: Francesca.bottanelli@fu-berlin.de

          • 216406b Laboratory Course
            Gene editing with CRISPR/Cas9 for cell biology (Francesca Bottanelli)
            Schedule: block course 02.02. - 13.02.26; 09:00 h, all day (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
            Location: Thielallee 63, Rauminformation über Blackboard (AG Bottanelli)
            

            Comments

            Content:
            The students will learn:
            • How to use bio-informatic tools for CRISPR/Cas9 technology
            • How to clone all the required plasmids for the insertion of tags into the genomic locus of genes of interest
            • How to culture and transfect human cell culture models
            
            Prof. Dr. Bottanelli: Francesca.bottanelli@fu-berlin.de

          • 216601a Seminar
            Cell biology (advanced course): Signal transduction (Petra Knaus)
            Schedule: Seminar: 09.03. - 20.03.26 , 1st week: Mo. 9:00-11:00 am, Tue.-Thu. 10:00 - 11:30 am 2nd week: Thu. 9:00 am - 06:00 pm, Fri. 9:00 am - 01:00 pm
            Location: Thielallee 63, room 221 (Knaus group) and Onlinelehre – zeitABhängig.
            

            Information for students

            Attention: changes in timetable are possible, after enrollment for the course you will be informed via e-mail

            Comments

            Seminar content:
            

            • The current view on BMP and TGFß signal transduction beyond the fundamental knowledge (intracellular and extracellular modulators, the importance of intensity and kinetics as well as subcellular localization of effector proteins, crosstalk mechanisms between related pathways).
            • Step-by-Step experimental outline and rational to address each individual step of signal transduction starting with ligand binding to the receptors, receptor activation and intracellular activation and shuttling of SMAD transcription factors binding to the DNA upon nuclear import.
            • How to investigate the different steps of signal transduction by complementary methods.
            • Paper discussion (presented by the students) focusing on recent papers that have been influential in the current view on BMP and TGFß signal transduction.
            • Intense practical and theoretical supervision due to the limited number of participants.
            
            
            Prof. Dr. P. Knaus: knaus@chemie.fu-berlin.de
            

          • 216601b Laboratory Course
            Cell biology (advanced course): Signal transduction (Petra Knaus)
            Schedule: block course: 09.03. - 20.03.26, with seminars; (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
            Location: Thielallee 63, Raum 001 and 004/005 (Labore)
            

            Comments

            Practical content:
            

            • Studying BMP/TGFß- induced signal transduction on multiple levels of the signaling cascade
            • Use of biochemical assays which allow to analyze BMP/TGFß signal transduction in a quantitative manner (qRT-PCR, quantitative Western-Blotting)
            • Use of biochemical assays which allow for analysis of BMP/TGFß signal transduction in a kinetic manner. Ligand stimulation, transcription factor translocation events, use of Luciferase-based reporter gene assay, activation of BMP-SMAD target genes
            • Use of biochemical assays which allow to analyze BMP/TGFß signal transduction with spatial resolution, subcellular localization of transcription factors using fluorescence microscopy
            • Using tools/strategies to artificially manipulate signal transduction (small molecule inhibitors targeting receptor-kinase activity, overexpression of tagged proteins of the BMP signal transduction cascade by transient-transfection methodology of overexpression plasmids.
            • Extensive discussion on experimental design, drawbacks and pitfalls when designing an experiment to investigate signal transduction.
            • Extensive discussions on appropriate controls to be implemented into the experimental design.
            • Summary of the experimental results by simulating how to write a primary research paper.
            
            
            Prof. Dr. P. Knaus: knaus@chemie.fu-berlin.de
            

        • Methods in Cell Biology (5 LP)

          0390bB1.5
          • 216202a Seminar
            Quantitative Fluorescence Microscopy (Helge Ewers, Bas van Bommel)
            Schedule: Block seminar: 19.01. - 30.01.2026; 9:00 h (Class starts on: 2026-01-19)
            Location: Thielallee 63, Seminarraum (Anbau)
            

            Information for students

            This seminar is one part of the methods course "Quantitative Fluorescence Microscopy" and takes place in parallel to the practical course. The seminar can be taken as theoretical module for the area structural biochemistry.

            Comments

            Learning aims: The students will develop an overview of the capabilities of modern light microscopy and a basic understanding of the role of sample preparation and imaging in the formation of quantitative digital data. The students will get insight into the basics of computational image analysis and how data can be extracted from digital image data. The students will learn how to analyze digital images and how to recognize and avoid mistakes in image analysis. Contents: - Fundamentals of fluorescence microscopy - Basics of digital imaging - Fundamental image analysis - Special methods in microscopy - Single molecule microscopy - superresolution microscopy - Fluorescence resonant energy transfer - Machine learning in image analysis Prof. Dr. H. Ewers: helge.ewers@fu-berlin.de Dr. Bas van Bommel: bas.van.bommel@fu-berlin.de

          • 216202b Laboratory Course
            Quantitative Fluorescence Microscopy (Helge Ewers, Bas van Bommel)
            Schedule: Block course: 19.01. - 30.01.2026; all-day (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
            Location: Thielallee 63, Raum 106a (AG Ewers)
            

            Information for students

            Practical part of the methods course "Quantitative Fluorescence Microscopy". The seminar is required to take part in the practical.

            Comments

            Learning aims: The students will generate samples for fluorescence microscopy and acquire images at the confocal and single molecule microscope. They will execute a number of experiments and analyze the acquired data using image J and other software. The students will train a deep-learning model and analyze the data they acquired themselves in superresolution microscopy. The students will critically evaluate the capabilities of modern microscopy techniques from literature research and present them to their peers. Contents: • Live-cell microscopy • Image generation, resolution and point-spread function • Background, Noise, extraktion of quantitative data • Use of Image J • Fluorescence-Recovery after Photobleaching • Single molecule superresolution microscopy • Image analysis with Deep-Learning Prof. Dr. H. Ewers: helge.ewers@fu-berlin.de Dr. Bas van Bommel: bas.van.bommel@fu-berlin.de

          • 216406a Seminar
            Gene editing with CRISPR/Cas9 for cell biology (Francesca Bottanelli)
            Schedule: block course 02.02. - 13.02.26; 09:00-10:00 h The exact schedule will be announced during the seminar.
            Location: Thielallee 63, Raum 321 (AG Bottanelli)
            

            Information for students

            The seminar is limited to 10 students. Please register via mail to: bottanelli@zedat.fu-berlin.de until 19.12.2025.

            Comments

            Content:
            The students will learn:
            • How to use bio-informatic tools for CRISPR/Cas9 technology
            • How to clone all the required plasmids for the insertion of tags into the genomic locus of genes of interest
            • How to culture and transfect human cell culture models
            
            Prof. Dr. Bottanelli: Francesca.bottanelli@fu-berlin.de

          • 216406b Laboratory Course
            Gene editing with CRISPR/Cas9 for cell biology (Francesca Bottanelli)
            Schedule: block course 02.02. - 13.02.26; 09:00 h, all day (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
            Location: Thielallee 63, Rauminformation über Blackboard (AG Bottanelli)
            

            Comments

            Content:
            The students will learn:
            • How to use bio-informatic tools for CRISPR/Cas9 technology
            • How to clone all the required plasmids for the insertion of tags into the genomic locus of genes of interest
            • How to culture and transfect human cell culture models
            
            Prof. Dr. Bottanelli: Francesca.bottanelli@fu-berlin.de

          • 216601a Seminar
            Cell biology (advanced course): Signal transduction (Petra Knaus)
            Schedule: Seminar: 09.03. - 20.03.26 , 1st week: Mo. 9:00-11:00 am, Tue.-Thu. 10:00 - 11:30 am 2nd week: Thu. 9:00 am - 06:00 pm, Fri. 9:00 am - 01:00 pm
            Location: Thielallee 63, room 221 (Knaus group) and Onlinelehre – zeitABhängig.
            

            Information for students

            Attention: changes in timetable are possible, after enrollment for the course you will be informed via e-mail

            Comments

            Seminar content:
            

            • The current view on BMP and TGFß signal transduction beyond the fundamental knowledge (intracellular and extracellular modulators, the importance of intensity and kinetics as well as subcellular localization of effector proteins, crosstalk mechanisms between related pathways).
            • Step-by-Step experimental outline and rational to address each individual step of signal transduction starting with ligand binding to the receptors, receptor activation and intracellular activation and shuttling of SMAD transcription factors binding to the DNA upon nuclear import.
            • How to investigate the different steps of signal transduction by complementary methods.
            • Paper discussion (presented by the students) focusing on recent papers that have been influential in the current view on BMP and TGFß signal transduction.
            • Intense practical and theoretical supervision due to the limited number of participants.
            
            
            Prof. Dr. P. Knaus: knaus@chemie.fu-berlin.de
            

          • 216601b Laboratory Course
            Cell biology (advanced course): Signal transduction (Petra Knaus)
            Schedule: block course: 09.03. - 20.03.26, with seminars; (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
            Location: Thielallee 63, Raum 001 and 004/005 (Labore)
            

            Comments

            Practical content:
            

            • Studying BMP/TGFß- induced signal transduction on multiple levels of the signaling cascade
            • Use of biochemical assays which allow to analyze BMP/TGFß signal transduction in a quantitative manner (qRT-PCR, quantitative Western-Blotting)
            • Use of biochemical assays which allow for analysis of BMP/TGFß signal transduction in a kinetic manner. Ligand stimulation, transcription factor translocation events, use of Luciferase-based reporter gene assay, activation of BMP-SMAD target genes
            • Use of biochemical assays which allow to analyze BMP/TGFß signal transduction with spatial resolution, subcellular localization of transcription factors using fluorescence microscopy
            • Using tools/strategies to artificially manipulate signal transduction (small molecule inhibitors targeting receptor-kinase activity, overexpression of tagged proteins of the BMP signal transduction cascade by transient-transfection methodology of overexpression plasmids.
            • Extensive discussion on experimental design, drawbacks and pitfalls when designing an experiment to investigate signal transduction.
            • Extensive discussions on appropriate controls to be implemented into the experimental design.
            • Summary of the experimental results by simulating how to write a primary research paper.
            
            
            Prof. Dr. P. Knaus: knaus@chemie.fu-berlin.de
            

          • 216613a Seminar
            Molecular Pharmacology and Cellular Signal Transduction (Ralf Schülein, Volker Haucke)
            Schedule: block seminar and practical course S/P: 16.03. - 27.03.26, 9:00 - 17:00 h; Seminar Di - Fr 9:00 - 10:30 h
            Location: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) , Robert-Rössle-Str. 10, 13125 Berlin Buch
            

            Information for students

            Seminar is included in the 2 week practical course

            Comments

            Exemplary seminar content:
            

            • Mechanoreception
            • Epigenetic mechanisms downstream of Wnt/beta-catenin in carcinomas and cancer stem cells
            • CIC chloride channels and transporters: insights from knockout mice and inherited diseases
            • G protein-coupled receptors and effector systems
            • Identification of novel drugs using high throughput screening
            • Ligand-gated ion channels
            • Neurotransmitter release and vesicle recycling
            • Protein conjugates
            
            
            Prof. Dr. R. Schülein: schuelein@fmp-berlin.de

          • 216613b Laboratory Course
            Molecular Pharmacology and Cellular Signal Transduction (Ralf Schülein, Volker Haucke)
            Schedule: block seminar and practical course S/P: 16.03. - 27.03.26, 9:00 - 17:00 h; Seminar Di - Fr 9:00 - 10:30 h (Tombola – Attention: the distribution mode has been changed. Please refer to the notice at the beginning of the course catalog.)
            Location: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) , Robert-Rössle-Str. 10, 13125 Berlin Buch
            

            Information for students

            Practical course with integrated seminar.

            Comments

            Practical content:
            

            • TIRF microscopy
            • Molecular modelling
            • Signaling by inositol pyrophosphates
            • Mass spectrometry and proteomics
            • Transgenic animals
            • Proteostasis in C. elegans
            • Voltage clamp
            • NMR spectroscopy
            
            
            Prof. Dr. R. Schülein: schuelein@fmp-berlin.de

            • Methods in Computational Biology, Bioinformatics and Data Analysis (5 LP)

              0390bB1.6
              • 216202a Seminar
                Quantitative Fluorescence Microscopy (Helge Ewers, Bas van Bommel)
                Schedule: Block seminar: 19.01. - 30.01.2026; 9:00 h (Class starts on: 2026-01-19)
                Location: Thielallee 63, Seminarraum (Anbau)
                

                Information for students

                This seminar is one part of the methods course "Quantitative Fluorescence Microscopy" and takes place in parallel to the practical course. The seminar can be taken as theoretical module for the area structural biochemistry.

                Comments

                Learning aims: The students will develop an overview of the capabilities of modern light microscopy and a basic understanding of the role of sample preparation and imaging in the formation of quantitative digital data. The students will get insight into the basics of computational image analysis and how data can be extracted from digital image data. The students will learn how to analyze digital images and how to recognize and avoid mistakes in image analysis. Contents: - Fundamentals of fluorescence microscopy - Basics of digital imaging - Fundamental image analysis - Special methods in microscopy - Single molecule microscopy - superresolution microscopy - Fluorescence resonant energy transfer - Machine learning in image analysis Prof. Dr. H. Ewers: helge.ewers@fu-berlin.de Dr. Bas van Bommel: bas.van.bommel@fu-berlin.de

              • 216202b Laboratory Course
                Quantitative Fluorescence Microscopy (Helge Ewers, Bas van Bommel)
                Schedule: Block course: 19.01. - 30.01.2026; all-day (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
                Location: Thielallee 63, Raum 106a (AG Ewers)
                

                Information for students

                Practical part of the methods course "Quantitative Fluorescence Microscopy". The seminar is required to take part in the practical.

                Comments

                Learning aims: The students will generate samples for fluorescence microscopy and acquire images at the confocal and single molecule microscope. They will execute a number of experiments and analyze the acquired data using image J and other software. The students will train a deep-learning model and analyze the data they acquired themselves in superresolution microscopy. The students will critically evaluate the capabilities of modern microscopy techniques from literature research and present them to their peers. Contents: • Live-cell microscopy • Image generation, resolution and point-spread function • Background, Noise, extraktion of quantitative data • Use of Image J • Fluorescence-Recovery after Photobleaching • Single molecule superresolution microscopy • Image analysis with Deep-Learning Prof. Dr. H. Ewers: helge.ewers@fu-berlin.de Dr. Bas van Bommel: bas.van.bommel@fu-berlin.de

              • 216404a Seminar
                Seminar on Bioanalytical Mass Spectrometry / Proteomic Analysis (Benno Kuropka)
                Schedule: block course: 17.11.- 28.11.2025; 9:00 - 10:30 h
                Location: Thielallee 63, Seminarraum (Anbau)
                

                Comments

                 

                • Fundamentals of proteome analysis
                • Technical basics of a mass spectrometer
                • Sample preparation and chromatographic peptide separation
                • Ionization methods (ESI and MALDI)
                • Protein identification by MALDI peptide mass fingerprinting
                • Methods for protein analysis (top-down, bottom-up, targeted)
                • Fragmentation methods and interpretation of MS/MS spectra for sequence determination
                • Methods of quantitative proteome analysis including different labeling techniques
                • Identification of protein interactions by affinity-purification MS
                • Analysis of non-covalent protein interactions using native MS
                • Guest Seminars on different topics: e.g. MALDI imaging, crosslinking-MS, carbohydrate analysis, metabolomics
                Dr. Benno Kuropka: kuropka@zedat.fu-berlin.de

              • 216404b Laboratory Course
                Bioanalytical Mass Spectrometry / Proteomic Analysis (Benno Kuropka)
                Schedule: block course 17.11. - 28.11.2025; 10:30h -17:00 h (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
                Location: Thielallee 63, Raum 316 (Labor)
                

                Information for students

                Additional information / Pre-requisites

                Comments

                • Protein identification by MALDI peptide mass fingerprint (PMF) after enzymatic in-gel cleavage.
                • Measurement of intact protein mass by MALDI-MS and sequencing by in source decay (ISD).
                • Quantitative proteome analysis using LC-ESI-MS.
                • High-resolution measurement of intact proteins under denaturing and native conditions (Orbitrap ESI-MS).

                 

                 

                Dr. Benno Kuropka: kuropka@zedat.fu-berlin.de

              • 216405a Seminar
                Mechanisms of Alternative Splicing Regulation (Florian Heyd, Marco Preußner)
                Schedule: block seminar: 19.01.26 - 30.01.26; begin: 19.01.26, 9:00 h, The exact schedule will be announced during the first course day.
                Location: Takustr. 6, room 003 (seminar room)
                

                Information for students

                Das Seminar findet parallel zum Praktikum statt.

                Comments

                Content:
                

                • RNA world model
                • Properties of nucleic acids
                • Chemical synthesis of DNA and RNA
                • Purification of oligonucleotides
                • Chemical synthesis of modified nucleic acids
                • Structural analysis of nucleic acids
                • Small and large ribozymes
                • Noncoding RNAs
                • Antisense strategies and RNA interference
                • Design of aptamers and spiegelmers
                • Biochip developments with nucleic acids
                • Biosensors employing nucleic acids
                • Nucleic acids as novel diagnostics
                • Clinical developments with nucleic acid drugs
                • Abzymes and aptazymes
                • Protein design through display strategies
                
                Prof. Dr. F. Heyd: florian.heyd@fu-berlin.de Dr. Marco Preußner: mpreussner@zedat.fu-berlin.de

              • 216405b Laboratory Course
                Mechanisms of Alternative Splicing Regulation (Florian Heyd, Marco Preußner)
                Schedule: block seminar and practical course: 19.01.26 - 30.01.26, all day, (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
                Location: Takustr. 6, room 001-002 (laboratory)
                

                Information for students

                Die Teilnahme am Seminar ist Voraussetzung für die Teilnahme am Praktikum.

                Comments

                Content:

                • Safe handling of radioisotopes
                • Chemical synthesis of oligonucleotides
                • Purification of oligonucleotides via HPLC
                • Purification of oligonucleotides via PAGE
                • Radioactive Labeling of oligonucleotides
                • Single-turnover kinetics on hammerhead ribozymes
                • Purification of target proteins
                • Synthesis of a combinatorial RNA library
                • Enrichment of oligoribonucleotides binding to a target
                • cDNA synthesis via reverse transcription
                • PCR amplification
                
                Prof. Dr. F. Heyd: florian.heyd@fu-berlin.de Dr. Marco Preußner: mpreussner@zedat.fu-berlin.de

              • 216602a Seminar
                Molecular Immunology (Christian Freund, Jana Sticht)
                Schedule: block course: 03.11.-14.11.25 (Class starts on: 2025-11-03)
                Location: Thielallee 63, Seminarraum (Anbau)
                

                Information for students

                The seminars are limited to 4 students in addition to the 6 students participating in the practical course 216602b. Please enrol via Email to: chfreund@zedat.fu-berlin.de AND sticht@zedat.fu-berlin.de
                until 15th Oktober 2025.

                Comments

                Inhalt/Content:
                

                - Introduction to Immunology: Innate and adaptive immune responses

                - The adaptive immune system: B and T cells

                - The adaptive immune system: antigen presentation by MHC molecules

                - Investigating MHC-peptide complexes by NMR spectroscopy

                - Immunopeptidomics (Mass spectrometry analysis of peptide presentation)

                - PyMol to visualize and analyze protein structures
                
                Prof. Dr. C. Freund: chfreund@zedat.fu-berlin.de
                Dr. J. Sticht: sticht@zedat.fu-berlin.de

              • 216602b Laboratory Course
                Molecular Immunology (Christian Freund, Jana Sticht)
                Schedule: block course: 03.11.-14.11.25 (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
                Location: Thielallee 63, Raum 016/018 und 025/027 (AG Freund)
                

                Comments

                Content:
                

                - MHC-peptide exchange experiments
                - Measuring the stability of MHC-peptide complexes
                - NMR of MHC-peptide complexes
                - Visualization of mutations and mapped epitopes in PyMol
                - Immunopeptidomics I - Affinity purification
                - Immunopeptidomics II - MS analysis and epitope prediction for T cell antigens
                
                Prof. Dr. C. Freund: chfreund@zedat.fu-berlin.de
                Dr. J. Sticht: sticht@zedat.fu-berlin.de

            • Methods in Molecular Biomedicine (5 LP)

              0390bB1.7
              • 216202a Seminar
                Quantitative Fluorescence Microscopy (Helge Ewers, Bas van Bommel)
                Schedule: Block seminar: 19.01. - 30.01.2026; 9:00 h (Class starts on: 2026-01-19)
                Location: Thielallee 63, Seminarraum (Anbau)
                

                Information for students

                This seminar is one part of the methods course "Quantitative Fluorescence Microscopy" and takes place in parallel to the practical course. The seminar can be taken as theoretical module for the area structural biochemistry.

                Comments

                Learning aims: The students will develop an overview of the capabilities of modern light microscopy and a basic understanding of the role of sample preparation and imaging in the formation of quantitative digital data. The students will get insight into the basics of computational image analysis and how data can be extracted from digital image data. The students will learn how to analyze digital images and how to recognize and avoid mistakes in image analysis. Contents: - Fundamentals of fluorescence microscopy - Basics of digital imaging - Fundamental image analysis - Special methods in microscopy - Single molecule microscopy - superresolution microscopy - Fluorescence resonant energy transfer - Machine learning in image analysis Prof. Dr. H. Ewers: helge.ewers@fu-berlin.de Dr. Bas van Bommel: bas.van.bommel@fu-berlin.de

              • 216202b Laboratory Course
                Quantitative Fluorescence Microscopy (Helge Ewers, Bas van Bommel)
                Schedule: Block course: 19.01. - 30.01.2026; all-day (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
                Location: Thielallee 63, Raum 106a (AG Ewers)
                

                Information for students

                Practical part of the methods course "Quantitative Fluorescence Microscopy". The seminar is required to take part in the practical.

                Comments

                Learning aims: The students will generate samples for fluorescence microscopy and acquire images at the confocal and single molecule microscope. They will execute a number of experiments and analyze the acquired data using image J and other software. The students will train a deep-learning model and analyze the data they acquired themselves in superresolution microscopy. The students will critically evaluate the capabilities of modern microscopy techniques from literature research and present them to their peers. Contents: • Live-cell microscopy • Image generation, resolution and point-spread function • Background, Noise, extraktion of quantitative data • Use of Image J • Fluorescence-Recovery after Photobleaching • Single molecule superresolution microscopy • Image analysis with Deep-Learning Prof. Dr. H. Ewers: helge.ewers@fu-berlin.de Dr. Bas van Bommel: bas.van.bommel@fu-berlin.de

              • 216404a Seminar
                Seminar on Bioanalytical Mass Spectrometry / Proteomic Analysis (Benno Kuropka)
                Schedule: block course: 17.11.- 28.11.2025; 9:00 - 10:30 h
                Location: Thielallee 63, Seminarraum (Anbau)
                

                Comments

                 

                • Fundamentals of proteome analysis
                • Technical basics of a mass spectrometer
                • Sample preparation and chromatographic peptide separation
                • Ionization methods (ESI and MALDI)
                • Protein identification by MALDI peptide mass fingerprinting
                • Methods for protein analysis (top-down, bottom-up, targeted)
                • Fragmentation methods and interpretation of MS/MS spectra for sequence determination
                • Methods of quantitative proteome analysis including different labeling techniques
                • Identification of protein interactions by affinity-purification MS
                • Analysis of non-covalent protein interactions using native MS
                • Guest Seminars on different topics: e.g. MALDI imaging, crosslinking-MS, carbohydrate analysis, metabolomics
                Dr. Benno Kuropka: kuropka@zedat.fu-berlin.de

              • 216404b Laboratory Course
                Bioanalytical Mass Spectrometry / Proteomic Analysis (Benno Kuropka)
                Schedule: block course 17.11. - 28.11.2025; 10:30h -17:00 h (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
                Location: Thielallee 63, Raum 316 (Labor)
                

                Information for students

                Additional information / Pre-requisites

                Comments

                • Protein identification by MALDI peptide mass fingerprint (PMF) after enzymatic in-gel cleavage.
                • Measurement of intact protein mass by MALDI-MS and sequencing by in source decay (ISD).
                • Quantitative proteome analysis using LC-ESI-MS.
                • High-resolution measurement of intact proteins under denaturing and native conditions (Orbitrap ESI-MS).

                 

                 

                Dr. Benno Kuropka: kuropka@zedat.fu-berlin.de

              • 216405a Seminar
                Mechanisms of Alternative Splicing Regulation (Florian Heyd, Marco Preußner)
                Schedule: block seminar: 19.01.26 - 30.01.26; begin: 19.01.26, 9:00 h, The exact schedule will be announced during the first course day.
                Location: Takustr. 6, room 003 (seminar room)
                

                Information for students

                Das Seminar findet parallel zum Praktikum statt.

                Comments

                Content:
                

                • RNA world model
                • Properties of nucleic acids
                • Chemical synthesis of DNA and RNA
                • Purification of oligonucleotides
                • Chemical synthesis of modified nucleic acids
                • Structural analysis of nucleic acids
                • Small and large ribozymes
                • Noncoding RNAs
                • Antisense strategies and RNA interference
                • Design of aptamers and spiegelmers
                • Biochip developments with nucleic acids
                • Biosensors employing nucleic acids
                • Nucleic acids as novel diagnostics
                • Clinical developments with nucleic acid drugs
                • Abzymes and aptazymes
                • Protein design through display strategies
                
                Prof. Dr. F. Heyd: florian.heyd@fu-berlin.de Dr. Marco Preußner: mpreussner@zedat.fu-berlin.de

              • 216405b Laboratory Course
                Mechanisms of Alternative Splicing Regulation (Florian Heyd, Marco Preußner)
                Schedule: block seminar and practical course: 19.01.26 - 30.01.26, all day, (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
                Location: Takustr. 6, room 001-002 (laboratory)
                

                Information for students

                Die Teilnahme am Seminar ist Voraussetzung für die Teilnahme am Praktikum.

                Comments

                Content:

                • Safe handling of radioisotopes
                • Chemical synthesis of oligonucleotides
                • Purification of oligonucleotides via HPLC
                • Purification of oligonucleotides via PAGE
                • Radioactive Labeling of oligonucleotides
                • Single-turnover kinetics on hammerhead ribozymes
                • Purification of target proteins
                • Synthesis of a combinatorial RNA library
                • Enrichment of oligoribonucleotides binding to a target
                • cDNA synthesis via reverse transcription
                • PCR amplification
                
                Prof. Dr. F. Heyd: florian.heyd@fu-berlin.de Dr. Marco Preußner: mpreussner@zedat.fu-berlin.de

              • 216406a Seminar
                Gene editing with CRISPR/Cas9 for cell biology (Francesca Bottanelli)
                Schedule: block course 02.02. - 13.02.26; 09:00-10:00 h The exact schedule will be announced during the seminar.
                Location: Thielallee 63, Raum 321 (AG Bottanelli)
                

                Information for students

                The seminar is limited to 10 students. Please register via mail to: bottanelli@zedat.fu-berlin.de until 19.12.2025.

                Comments

                Content:
                The students will learn:
                • How to use bio-informatic tools for CRISPR/Cas9 technology
                • How to clone all the required plasmids for the insertion of tags into the genomic locus of genes of interest
                • How to culture and transfect human cell culture models
                
                Prof. Dr. Bottanelli: Francesca.bottanelli@fu-berlin.de

              • 216406b Laboratory Course
                Gene editing with CRISPR/Cas9 for cell biology (Francesca Bottanelli)
                Schedule: block course 02.02. - 13.02.26; 09:00 h, all day (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
                Location: Thielallee 63, Rauminformation über Blackboard (AG Bottanelli)
                

                Comments

                Content:
                The students will learn:
                • How to use bio-informatic tools for CRISPR/Cas9 technology
                • How to clone all the required plasmids for the insertion of tags into the genomic locus of genes of interest
                • How to culture and transfect human cell culture models
                
                Prof. Dr. Bottanelli: Francesca.bottanelli@fu-berlin.de

              • 216601a Seminar
                Cell biology (advanced course): Signal transduction (Petra Knaus)
                Schedule: Seminar: 09.03. - 20.03.26 , 1st week: Mo. 9:00-11:00 am, Tue.-Thu. 10:00 - 11:30 am 2nd week: Thu. 9:00 am - 06:00 pm, Fri. 9:00 am - 01:00 pm
                Location: Thielallee 63, room 221 (Knaus group) and Onlinelehre – zeitABhängig.
                

                Information for students

                Attention: changes in timetable are possible, after enrollment for the course you will be informed via e-mail

                Comments

                Seminar content:
                

                • The current view on BMP and TGFß signal transduction beyond the fundamental knowledge (intracellular and extracellular modulators, the importance of intensity and kinetics as well as subcellular localization of effector proteins, crosstalk mechanisms between related pathways).
                • Step-by-Step experimental outline and rational to address each individual step of signal transduction starting with ligand binding to the receptors, receptor activation and intracellular activation and shuttling of SMAD transcription factors binding to the DNA upon nuclear import.
                • How to investigate the different steps of signal transduction by complementary methods.
                • Paper discussion (presented by the students) focusing on recent papers that have been influential in the current view on BMP and TGFß signal transduction.
                • Intense practical and theoretical supervision due to the limited number of participants.
                
                
                Prof. Dr. P. Knaus: knaus@chemie.fu-berlin.de
                

              • 216601b Laboratory Course
                Cell biology (advanced course): Signal transduction (Petra Knaus)
                Schedule: block course: 09.03. - 20.03.26, with seminars; (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
                Location: Thielallee 63, Raum 001 and 004/005 (Labore)
                

                Comments

                Practical content:
                

                • Studying BMP/TGFß- induced signal transduction on multiple levels of the signaling cascade
                • Use of biochemical assays which allow to analyze BMP/TGFß signal transduction in a quantitative manner (qRT-PCR, quantitative Western-Blotting)
                • Use of biochemical assays which allow for analysis of BMP/TGFß signal transduction in a kinetic manner. Ligand stimulation, transcription factor translocation events, use of Luciferase-based reporter gene assay, activation of BMP-SMAD target genes
                • Use of biochemical assays which allow to analyze BMP/TGFß signal transduction with spatial resolution, subcellular localization of transcription factors using fluorescence microscopy
                • Using tools/strategies to artificially manipulate signal transduction (small molecule inhibitors targeting receptor-kinase activity, overexpression of tagged proteins of the BMP signal transduction cascade by transient-transfection methodology of overexpression plasmids.
                • Extensive discussion on experimental design, drawbacks and pitfalls when designing an experiment to investigate signal transduction.
                • Extensive discussions on appropriate controls to be implemented into the experimental design.
                • Summary of the experimental results by simulating how to write a primary research paper.
                
                
                Prof. Dr. P. Knaus: knaus@chemie.fu-berlin.de
                

              • 216602a Seminar
                Molecular Immunology (Christian Freund, Jana Sticht)
                Schedule: block course: 03.11.-14.11.25 (Class starts on: 2025-11-03)
                Location: Thielallee 63, Seminarraum (Anbau)
                

                Information for students

                The seminars are limited to 4 students in addition to the 6 students participating in the practical course 216602b. Please enrol via Email to: chfreund@zedat.fu-berlin.de AND sticht@zedat.fu-berlin.de
                until 15th Oktober 2025.

                Comments

                Inhalt/Content:
                

                - Introduction to Immunology: Innate and adaptive immune responses

                - The adaptive immune system: B and T cells

                - The adaptive immune system: antigen presentation by MHC molecules

                - Investigating MHC-peptide complexes by NMR spectroscopy

                - Immunopeptidomics (Mass spectrometry analysis of peptide presentation)

                - PyMol to visualize and analyze protein structures
                
                Prof. Dr. C. Freund: chfreund@zedat.fu-berlin.de
                Dr. J. Sticht: sticht@zedat.fu-berlin.de

              • 216602b Laboratory Course
                Molecular Immunology (Christian Freund, Jana Sticht)
                Schedule: block course: 03.11.-14.11.25 (Tombola – Attention: the distribution mode has been changed. For further information, please refer to the notice at the beginning of the course catalog.)
                Location: Thielallee 63, Raum 016/018 und 025/027 (AG Freund)
                

                Comments

                Content:
                

                - MHC-peptide exchange experiments
                - Measuring the stability of MHC-peptide complexes
                - NMR of MHC-peptide complexes
                - Visualization of mutations and mapped epitopes in PyMol
                - Immunopeptidomics I - Affinity purification
                - Immunopeptidomics II - MS analysis and epitope prediction for T cell antigens
                
                Prof. Dr. C. Freund: chfreund@zedat.fu-berlin.de
                Dr. J. Sticht: sticht@zedat.fu-berlin.de

              • 216613a Seminar
                Molecular Pharmacology and Cellular Signal Transduction (Ralf Schülein, Volker Haucke)
                Schedule: block seminar and practical course S/P: 16.03. - 27.03.26, 9:00 - 17:00 h; Seminar Di - Fr 9:00 - 10:30 h
                Location: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) , Robert-Rössle-Str. 10, 13125 Berlin Buch
                

                Information for students

                Seminar is included in the 2 week practical course

                Comments

                Exemplary seminar content:
                

                • Mechanoreception
                • Epigenetic mechanisms downstream of Wnt/beta-catenin in carcinomas and cancer stem cells
                • CIC chloride channels and transporters: insights from knockout mice and inherited diseases
                • G protein-coupled receptors and effector systems
                • Identification of novel drugs using high throughput screening
                • Ligand-gated ion channels
                • Neurotransmitter release and vesicle recycling
                • Protein conjugates
                
                
                Prof. Dr. R. Schülein: schuelein@fmp-berlin.de

              • 216613b Laboratory Course
                Molecular Pharmacology and Cellular Signal Transduction (Ralf Schülein, Volker Haucke)
                Schedule: block seminar and practical course S/P: 16.03. - 27.03.26, 9:00 - 17:00 h; Seminar Di - Fr 9:00 - 10:30 h (Tombola – Attention: the distribution mode has been changed. Please refer to the notice at the beginning of the course catalog.)
                Location: Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) , Robert-Rössle-Str. 10, 13125 Berlin Buch
                

                Information for students

                Practical course with integrated seminar.

                Comments

                Practical content:
                

                • TIRF microscopy
                • Molecular modelling
                • Signaling by inositol pyrophosphates
                • Mass spectrometry and proteomics
                • Transgenic animals
                • Proteostasis in C. elegans
                • Voltage clamp
                • NMR spectroscopy
                
                
                Prof. Dr. R. Schülein: schuelein@fmp-berlin.de

                • Research Project in Literature Search and Research Design (5 LP)

                  0390bB2.1
                  • 216881a Seminar
                    Research Seminar: Literature Search and Research Design / Literaturrecherche und Forschungskonzeption (Florian Heyd)
                    Schedule: Information about the further process will follow on Blackboard.
                    Location: Information about the further process will follow on Blackboard.
                    

                    Additional information / Pre-requisites

                    Zeit und Ort bitte bei den Dozenten erfragen.
                    Begrenzte Teilnehmerzahl

                    Comments

                    Content:
                    

                    • Overview of funding schemes
                    • Contents of a grant proposal
                    • Literature search
                    • Conceptualizing a scientific project
                    • Presentation of a research topic
                    
                    
                    
                    Prof. Dr. F. Heyd: florian.heyd@fu-berlin.de
                    

                • Research Project in Research Design and Grant Writing (10 LP)

                  0390bB2.2
                  • 216881b Internship
                    Research Practical - Research Design and Grant Writing / Forschungskonzeption und Antragstellung (Francesca Bottanelli, Sutapa Chakrabarti, Helge Ewers, Christian Freund, Lydia Herzel, Florian Heyd, Petra Knaus, Markus Wahl)
                    Schedule: Information about the further process will follow on Blackboard.
                    Location: Information about the further process will follow on Blackboard.
                    

                    Information for students

                    Attendance only possible after successful completion of 216881a

                    Additional information / Pre-requisites

                    For additional informations see 216881a

                    Comments

                    Content/Inhalt:
                    

                    • Literature search
                    • Conceptualizing a scientific project
                    • Writing of a grant proposal
                    • Presenting a proposed scientific project
                    • Peer-review of proposals
                    
                    Prof. Dr. S. Chakrabarti:chakraba@zedat.fu-berlin.de
                    Prof. Dr. F. Heyd: florian.heyd@fu-berlin.de
                    

                • Free elective module (5 LP)

                  0390bB4.1
                  • 21359 Lecture
                    Nanotechnology: Characterization of Nanomaterials in biological systems, absorption/biokinetics, exposure, and toxicity testing (Andrea Haase)
                    Schedule: Mo 10-12 Uhr (Beginn voraussichtlich 20.10.2025; Rückfragen bitte an: andrea.haase@bfr.bund.de (Class starts on: 2025-10-20)
                    Location: SR PTC (Raum A.006, EG) (Arnimallee 22)
                    

                    Information for students

                    Bitte die Ankündigungen in Blackboard beachten. Rückfragen bitte an: andrea.haase@bfr.bund.de

                    Comments

                    Nanotechnologie gilt weltweit als Schlüsseltechnologie. Nano- und andere innovative Materialien („Advanced Materials“) kommen in vielen unterschiedlichen Bereichen einschließlich der modernen Medizin zum EInsatz. In diesem Seminar erwerben die Studierenden einen Überblick über verschiedene innovative Materialklassen, deren Eigenschaften und ausgewählte Einsatzgebiete. Weiterhin erwerben sie Kenntnisse darüber, wie sich Materialien in biologischen Systemen verhalten. Schwerpunktmäßig geht es um ein fundiertes Verständnis möglicher adverser Effekte auf die menschliche Gesundheit, mögliche Expositionspfade sowie verschiedene Testmethoden zur Charakterisierung der Toxizität. Es werden neben Standardmethoden auch moderne toxikologische Untersuchungsverfahren besprochen, z.B. integrierte/ intelligente Testverfahren, automatisierte Hochdurchsatzverfahren und Omics-Techniken Die Studierenden erwerben Grundkenntnisse  der Risikobewertung.und gewinnen abschließend erste Einblicke in moderen Designprinzipien, die darauf abzielen bereits im Innovationsprozess Materialsicherheit zu berücksichtigen.
                    
                    Dieses Seminar beinhaltet die folgenden Themen:

                    • Charakterisierung von Nano- und anderen innovativen Materialien
                    • Interaktion mit biologischen Molekülen
                    • Aufnahme in Zellen, Gewebe, Organismen, Biokinetik
                    • Expositionspfade und Toxiizitätstestmethoden (in silico, in vitro, in vivo)
                    • Expositionsmessung und - modellierung
                    • Risikobewertung, Regulation
                    • Ansätze zu nachhaltigen Designprinzipien (Safe-and-Sustainable Innovation)

                    Suggested reading

                    Usmani et al. 2024. Review of New Approach Methodologies for Application in Risk Assessment of Nanoparticles in the Food and Feed Sector: Status and Challenges. EFSA supporting publication. DOI: https://doi.org/10.2903/sp.efsa.2024.EN-8826

                  • 216321a Seminar
                    Integrative Strucutural Biology (Oliver Daumke)
                    Schedule: Mo 9:15 - 10:15 h, Beginn 13.10.2025
                    Location: Online zeitAbhängig and Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Straße 10 13125 Berlin, Haus 31.2., SR 0211
                    

                    Information for students

                    Please contact Prof. Dr. O. Daumke (oliver.daumke@mdc-berlin.de) if you would like to participate.

                    Comments

                    Content:
                    Progress-report seminars on practical aspects of structural biology, including
                    

                    • concepts and design of studies in structural biology
                    • design of protein samples or complexes for structure analysis
                    • progress and problems in expression cloning and recombinant protein production in bacterial or eukaryotic hosts
                    • progress and problems in protein crystallization or cryo-EM sample preparation
                    • progress and problems in crystal structure analysis of biological macromolecules and complexes
                    • progress and problems in structure analysis by cryo-EM methods
                    • how to derive and test biological hypotheses from X-ray and cryo-EM structures
                    • biochemical studies of a variety of proteins, nucleic acids and complexes
                    
                    Contact:
                    Prof. Dr. O. Daumke: oliver.daumke@mdc-berlin.de

                  • 216321b Seminar
                    Current Structural Biology (Oliver Daumke)
                    Schedule: Mi 11:00 - 12:00 h, Beginn 15.10.25
                    Location: Online zeitAbhängig and Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Straße 10 13125 Berlin, Haus 31.2., SR 0211
                    

                    Information for students

                    Please contact Prof. Dr. O. Daumke (oliver.daumke@mdc-berlin.de) if you would like to participate.

                    Additional information / Pre-requisites

                    Please contact Prof. Dr. O. Daumke (oliver.daumke@mdc-berlin.de) if you would like to participate.

                    Comments

                    Content:
                    Journal-club seminars on various topics in structural biology, including:
                    

                    • new X-ray, NMR and cryo-EM structures
                    • method developments in macromolecular crystallography
                    • method developments in cryo-electron microscopy
                    • new concepts in molecular and cell biology
                    • current studies in membrane biology
                    • current studies in gene expression regulation
                    • structure-based identification and optimization of chemical probes
                    
                    Contact:
                    
                    Prof. Dr. O. Daumke: oliver.daumke@mdc-berlin.de

                  • 216501a Lecture
                    Membrane Proteins: Classification, Structure and Function (Stefan Kubick)
                    Schedule: Di 18:00 st. - 19:00 h (Class starts on: 2025-10-14)
                    Location: Hs Biochemie, Thielallee 63 (Lise-Meitner-Hörsaal)
                    

                    Information for students

                    Registration for the lecture by email to: stefan.kubick@fu-berlin.de) Then you will receive the access data. Classes 216501 a and b must be attended together. Their succesfull completion is obligatory for the application for the method module 216451 a, b!

                    Comments

                    Content:
                    Biomembranes and synthesis of transmembrane proteins:
                    

                    • Molecular structure of membranes
                    • Synthesis of biomembranes
                    • Lipid rafts
                    • Subcellular organization of the eukaryotic cell, cell metabolism and secretion
                    • Protein synthesis
                    
                    Receptors and signal transduction:
                    
                    • Cell surface receptors
                    • Signal transduction pathways
                    
                    Multigene families encoding membrane proteins:
                    
                    • G protein-coupled receptors (structure, signal transduction, agonists/antagonists)
                    • Odorant receptors
                    • Non-peptide receptors
                    • Peptide receptors
                    
                    Ion channels:
                    
                    • voltage-gated ion channels
                    • ligand-gated ion channels
                    • mechanosensitive ion channels
                    
                    Methods in molecular biology and protein chemistry:
                    
                    • Production of membrane proteins
                    • Cell-free protein synthesis (prokaryotic systems, eukaryotic systems, labeling)
                    • Structural and functional analysis of membrane proteins
                    
                    
                    Dr. S. Kubick: stefan.kubick@fu-berlin.de
                    

                  • 216501b Seminar
                    Membrane Proteins: Classification, Structure and Function (Stefan Kubick)
                    Schedule: Di 19:00 - 20:00 h (Class starts on: 2025-10-14)
                    Location: Hs Biochemie, Thielallee 63 (Lise-Meitner-Hörsaal)
                    

                    Information for students

                    Registration for the lecture by email to: stefan.kubick@fu-berlin.de) Then you will receive the access data Classes 216501 a and b must be attended together. Their succesfull completion is obligatory for the application for the method module 216451 a, b!

                    Comments

                    Inhalt / Content:
                    Intended for graduate students, this seminar will introduce the tools of membrane protein synthesis and their functional characterization. Membrane proteins account for more than 30% of the genome in living organisms and many membrane-embedded receptors, transporters and ion channels are important therapeutic targets. In this context, methodologies concerning the functional characterization, the structure and the biochemical properties of membrane proteins, their regulation and their physiological relevance are in the focus of this seminar. Emphasis is given to topics that will be useful in other disciplines, including systems for the in vivo and in vitro expression of membrane proteins. The seminar gives a detailed introduction on problems concerning the interaction of chemical messengers with specific cell-surface receptors, the activation of signal-transduction cascades leading to the accumulation of specific intracellular second messenger molecules and the cell’s response to an external stimulus. Beside others the following topics are discussed in detail: Ligand-gated ion channels and their signaling between electrically excitable cells; G protein-coupled receptors, triggering downstream signal transduction cascades, thereby activating separate membrane-associated enzymes and catalytic receptors, acting as enzymes themselves. A critical approach to lipid-membrane protein interactions and the pharmacological properties of selected membrane proteins is also in the focus of this seminar.
                    
                    Seminar takes place right after the lecture (s. above)
                    
                    Dr. S. Kubick: stefan.kubick@fu-berlin.de
                    Fraunhofer Institut für Zelltherapie und Immunologie (IZI), Institutsteil Bioanalytik und Bioprozesse(IZI-BB) Potsdam-Golm, Am Mühlenberg 13, 14476 Potsdam

                  • 216506 Seminar
                    Current Topics in Protein Biochemistry (Christian Freund)
                    Schedule: please contact the instructor for further information
                    Location: Seminarraum 021 (AG Freund), Thielallee 63
                    

                    Comments

                    Inhalt / Content:
                    

                    • Novel enzymes, unconventional catalysts
                    • Proteins in T cell activation and signaling
                    • Synaptic proteins and their interactions
                    • Actin regulatory proteins
                    • Proline-rich sequence (PRS) recognition domain containing proteins
                    
                    
                    Prof. Dr. C. Freund: chfreund@zedat.fu-berlin.de

                  • 216531 Seminar
                    Introduction to Epigenomics (Alexander Meissner)
                    Schedule: Thursday, 15.01.26 (9.30 - 17:00 h) and Friday 16.01.26 ( 09:30 - 16:00 h)
                    Location: MPIMG, Ihnestr. 63, Seminarraum S3, 14195 Berlin
                    

                    Information for students

                    Seminar is only in English.

                    Additional information / Pre-requisites

                    Comments

                    Content:
                    Chemical modifications to DNA and histone proteins form a complex regulatory network that modulates chromatin structure and genome function. The epigenome refers to the complete description of these potentially heritable changes across the genome. The composition of the epigenome within a given cell is a function of genetic determinants, lineage, and environment. With the sequencing of the human genome completed, investigators now seek a comprehensive view of the epigenetic changes that determine how genetic information is made manifest across an incredibly varied background of developmental stages, tissue types, and disease states.
                    Aim of the seminar is to provide a basic introduction to epigenetics including an overview and basic understanding of key technologies that produce today’s epigenomic data. On the second day basic data processing and analysis will be covered.
                    
                    Thursday: Introduction to Epigenetics Introduction to Next-Generation Sequencing Key technologies: DNA methylation mapping, Chromatin mapping, 3D architecture, long read sequencing Isolation of high molecular weight DNA (for long read sequencing), state-of-the-art library generation and QC, Sequencing Friday: From DNA sequencer to data analysis Nanopore sequencing and analysis (Epi)-Genome browsing Epigenetic deregulation in disease Prof. Dr. A Meißner: meissner@molgen.mpg.de

                  • 216542 Lecture
                    Emerging Viruses (Susann Kummer)
                    Schedule: 05.11. - 07.11.25, 12.11. - 14.11.25 and 19.11.-20.11.25 from 09:30 - 11.00 h
                    Location: Online - zeitABhängig
                    

                    Information for students

                    If you would like to participate please write to Dr. Susann Kummer: susann.kummer@fu-berlin.de

                    Comments

                    Description:
                    Introduction into principles of emerging viruses. The lecture will address the definition and description of emerging viruses and processes behind the development of emerging diseases. In the following examples of emerging viruses will be presented and their risk potential discussed. The topic of pandemic events, health care measures and ways to prevent and/or handle future pandemics will be part of the lecture series as well.
                    
                    1) Introduction, what are emerging viruses, what is an endemic/pandemic, history of pandemics and what we can learn from the past
                    2) Influenza viruses
                    3) SARS and MERS related corona viruses
                    4) Ebola viruses
                    5) human immunodeficiency viruses
                    6) Mosquito-transmitted viruses (ZIKA, Dengue, West Nile virus, Chikungunya, Yellow fever)
                    7) Emerging diseases in animals (risk potential for transfer to humans)
                    8) Emerging marine viruses and conclusions, open discussion, Q & A session to virus research related topics

                  • 216703 Seminar
                    Journal Club "Recent Topics in Signaltransduction" (Petra Knaus)
                    Schedule: expected to take place regularly on Thursdays, 9:30am (Hybrid format) please contact the instructor for further information.
                    Location: Thielallee 63, room 221 (Knaus group) and Online - zeitABhängig
                    
                  • 216709a Seminar
                    (S) Methods of Science Communication (Jerome Jatzlau)
                    Schedule: Takes place regularly on Tuesdays or Wednesdays, 18:00 h on site, please contact the instructor for further information. First Meeting: 15.10.2025
                    Location: Thielallee 63, Raum 221 (AG Knaus)
                    

                    Information for students

                    Seminar is open for both Bachelor and Master students independent of the semester. It is recommended to visit the course towards the end of the Bachelor studies or within the Master studies. Seminar will be on german or english. For registration send an e-mail to: jerome.jatzlau@fu-berlin.de with your name and your FU Student ID Nummer.

                    Comments

                    Content:
                    Students will get to known key aspects of good scientific communication. Further they will get to know different creative methods to express and communicate their scientific results to peers and the broader public. From the different methods students should select two to further explore and apply to a topic of their choice. This could be used as a preparation for any lab presentation of a research project or using a topic handed out by the instructors.
                    Methods include:
                    
                    • Science Slam
                    • 3D printing of scientific models
                    • 3D rendering & animation ( proteins, DNA, membranes, cells)
                    • Memes as vehicle of science communication
                    • Artifical intelligence for scientific graphic rendering
                    
                    Dr. J. Jatzlau: jerome.jatzlau@fu-berlin.de; L. Obendorf: leon.obendorf@fu-berlin.de
                    
                    

                  • 216709b Seminar
                    (P) Methods of Science Communication (Jerome Jatzlau)
                    Schedule: In preparation for the following week, course participants work on a practical creative project at home. The time required varies depending on the subject area. First date: 15.10.2025
                    Location: Thielallee 63, Raum 221 (AG Knaus)
                    

                    Information for students

                    Seminar is open for both Bachelor and Master students independent of the semester. It is recommended to visit the course towards the end of the Bachelor studies or within the Master studies. Seminar will be on german or english. For registration send an e-mail to: jerome.jatzlau@fu-berlin.de with your name and your FU Student ID Nummer.

                    Comments

                    Content:
                    Presentation of the chosen project.
                    Methods include:
                    
                    • Science Slam
                    • 3D printing of scientific models
                    • 3D rendering & animation ( proteins, DNA, membranes, cells)
                    • Memes as vehicle of science communication
                    • Artifical intelligence for scientific graphic rendering
                    
                    Dr. J. Jatzlau: jerome.jatzlau@fu-berlin.de; L. Obendorf: leon.obendorf@fu-berlin.de
                    
                    

                  • 216711a Seminar
                    Stem Cell Biology (Nan Ma)
                    Schedule: 13.10. - 10.11.2025, every Monday, 15:00 -19:00 h (Class starts on: 2025-10-13)
                    Location: PC-Pool Chemie (Raum A.-106, UG1) (Arnimallee 22)
                    

                    Information for students

                    Seminars 216711a and b must be attended together
                    For application directly contact the lecturer: Prof Dr. Nan Ma: nan.ma@fu-berlin.de

                    Comments

                    Content:
                    

                    • Stem cell and regenerative medicine
                    • Adult stem cell
                    • Embryonic stem cell
                    • Induced pluripotent stem cell
                    • Stem cell niche
                    • Technique of purification and characterization(FACS)
                    
                    
                    Prof. Dr. N. Ma: Nan.Ma@fu-berlin.de

                  • 216711b Seminar
                    Stem Cell Therapy (Nan Ma)
                    Schedule: 17.11.25 - 15.12.25 every monday, 15:00 -19:00 h (Class starts on: 2025-11-17)
                    Location: PC-Pool Chemie (Raum A.-106, UG1) (Arnimallee 22)
                    

                    Information for students

                    Seminars 216711a and b must be attended together
                    For application directly contact the lecturer: Prof Dr. Nan Ma: nan.ma@hereon.de

                    Comments

                    Content:
                    

                    • The basic of stem cell transplantation
                    • Hematopoietic stem cell transplantation(HSCT)
                    • Cancer stem cell and targeted therapy
                    • Skin stem cell and their clinical application
                    • Stem cell and cardiac repair
                    
                    
                    Prof Dr. N. Ma,: Nan.Ma@hzg.de

                  • 216741a Seminar
                    Molecular Virology (Annette Mankertz; Joachim Mankertz)
                    Schedule: Briefing: 15.10.25, 17:00 h Wednesday 17:00-18:30 h (a: 17:00 - 17:45 h, b: 17:45-18:30 h)
                    Location: Onlinelehre – zeitABhängig. Powerpoint with voice-over and/or videoconference at the regular time.
                    

                    Information for students

                    Given via video conference, interested students may enlist via E-Mail to mankertza@rki.de
                    
                    Seminars 216741a and b must be attended together
                    Some dates of the event may take place online
                    

                    Comments

                    Content: 45 min introduction to the topic by lecturer 15 min presentation of a paper by student with slides (plus 2 pages handout sent to all students) 30 min seminar with questions on specific points of the presentation and the lecture, discussion Prof. Dr. A. Prof. Dr. A. Mankertz:mankertza@rki.de
                    PD Dr. J. Mankertz:joachim.mankertz@bvl.bund.de

                  • 216741b Seminar
                    Spezielle molekulare Virologie (Annette Mankertz; Joachim Mankertz)
                    Schedule: Briefing: 15.10.25, 17:00 h Wednesday 17:00-18:30 h (a: 17:00 - 17:45 h, b: 17:45-18:30 h)
                    Location: Onlinelehre – zeitABhängig. Powerpoint with voice-over and/or videoconference at the regular time.
                    

                    Information for students

                    Seminars 216741a and b must be attended together Given via video conference, interested students may enlist via E-Mail to mankertza@rki.de

                    Comments

                    Content: 45 min introduction to the topic by lecturer 15 min presentation of a paper by student with slides (plus 2 pages handout sent to all students) 30 min seminar with questions on specific points of the presentation and the lecture, discussion Given via video conference, interested students may enlist via E-Mail to mankertza@rki.de
                    
                    Prof. Dr. A. Mankertz:mankertza@rki.de
                    PD Dr. J. Mankertz:joachim.mankertz@bvl.bund.de

                  • 216762 Seminar
                    The Drug Discovery Process in the Pharmaceutical Industry - From target to hit identification (Roman Hillig, Holger Steuber)
                    Schedule: Schedule: Di and Do, 08:00 - 09:30 h, duration: 04.11.25 - 27.11.25
                    Location: Online - zeitABhängig. Vertonte ppt und/oder Videokonferenz zur regulären Zeit.
                    

                    Information for students

                    Die Teile (I im SS und II im WS) können in beliebiger Reihenfolge besucht werden, sie sind nicht aufbauend.

                    Additional information / Pre-requisites

                    Seminars 216761 and 216762 can be attended in arbitrary sequence, they do not build-up on each other.

                    Comments

                    Content:
                    1. Target Identification and Hit Finding
                    2. X-ray Crystallography in DD
                    3. Molecular Modeling
                    4. Fragment-Based Drug Design
                    5. New Modalities, New target Classes
                    6. Target Class: Ras GTPase superfamily
                    7. Target Class: Epigenetic Targets
                    8. Nuclear Magnetic Resonance
                    
                    Dr. R. Hillig: roman.hillig@nuvisan.com
                    Dr. H. Steuber: holger.steuber@ nuvisan.com

                • Free elective module (5 LP)

                  0390bB4.2
                  • 21359 Lecture
                    Nanotechnology: Characterization of Nanomaterials in biological systems, absorption/biokinetics, exposure, and toxicity testing (Andrea Haase)
                    Schedule: Mo 10-12 Uhr (Beginn voraussichtlich 20.10.2025; Rückfragen bitte an: andrea.haase@bfr.bund.de (Class starts on: 2025-10-20)
                    Location: SR PTC (Raum A.006, EG) (Arnimallee 22)
                    

                    Information for students

                    Bitte die Ankündigungen in Blackboard beachten. Rückfragen bitte an: andrea.haase@bfr.bund.de

                    Comments

                    Nanotechnologie gilt weltweit als Schlüsseltechnologie. Nano- und andere innovative Materialien („Advanced Materials“) kommen in vielen unterschiedlichen Bereichen einschließlich der modernen Medizin zum EInsatz. In diesem Seminar erwerben die Studierenden einen Überblick über verschiedene innovative Materialklassen, deren Eigenschaften und ausgewählte Einsatzgebiete. Weiterhin erwerben sie Kenntnisse darüber, wie sich Materialien in biologischen Systemen verhalten. Schwerpunktmäßig geht es um ein fundiertes Verständnis möglicher adverser Effekte auf die menschliche Gesundheit, mögliche Expositionspfade sowie verschiedene Testmethoden zur Charakterisierung der Toxizität. Es werden neben Standardmethoden auch moderne toxikologische Untersuchungsverfahren besprochen, z.B. integrierte/ intelligente Testverfahren, automatisierte Hochdurchsatzverfahren und Omics-Techniken Die Studierenden erwerben Grundkenntnisse  der Risikobewertung.und gewinnen abschließend erste Einblicke in moderen Designprinzipien, die darauf abzielen bereits im Innovationsprozess Materialsicherheit zu berücksichtigen.
                    
                    Dieses Seminar beinhaltet die folgenden Themen:

                    • Charakterisierung von Nano- und anderen innovativen Materialien
                    • Interaktion mit biologischen Molekülen
                    • Aufnahme in Zellen, Gewebe, Organismen, Biokinetik
                    • Expositionspfade und Toxiizitätstestmethoden (in silico, in vitro, in vivo)
                    • Expositionsmessung und - modellierung
                    • Risikobewertung, Regulation
                    • Ansätze zu nachhaltigen Designprinzipien (Safe-and-Sustainable Innovation)

                    Suggested reading

                    Usmani et al. 2024. Review of New Approach Methodologies for Application in Risk Assessment of Nanoparticles in the Food and Feed Sector: Status and Challenges. EFSA supporting publication. DOI: https://doi.org/10.2903/sp.efsa.2024.EN-8826

                  • 216321a Seminar
                    Integrative Strucutural Biology (Oliver Daumke)
                    Schedule: Mo 9:15 - 10:15 h, Beginn 13.10.2025
                    Location: Online zeitAbhängig and Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Straße 10 13125 Berlin, Haus 31.2., SR 0211
                    

                    Information for students

                    Please contact Prof. Dr. O. Daumke (oliver.daumke@mdc-berlin.de) if you would like to participate.

                    Comments

                    Content:
                    Progress-report seminars on practical aspects of structural biology, including
                    

                    • concepts and design of studies in structural biology
                    • design of protein samples or complexes for structure analysis
                    • progress and problems in expression cloning and recombinant protein production in bacterial or eukaryotic hosts
                    • progress and problems in protein crystallization or cryo-EM sample preparation
                    • progress and problems in crystal structure analysis of biological macromolecules and complexes
                    • progress and problems in structure analysis by cryo-EM methods
                    • how to derive and test biological hypotheses from X-ray and cryo-EM structures
                    • biochemical studies of a variety of proteins, nucleic acids and complexes
                    
                    Contact:
                    Prof. Dr. O. Daumke: oliver.daumke@mdc-berlin.de

                  • 216321b Seminar
                    Current Structural Biology (Oliver Daumke)
                    Schedule: Mi 11:00 - 12:00 h, Beginn 15.10.25
                    Location: Online zeitAbhängig and Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Straße 10 13125 Berlin, Haus 31.2., SR 0211
                    

                    Information for students

                    Please contact Prof. Dr. O. Daumke (oliver.daumke@mdc-berlin.de) if you would like to participate.

                    Additional information / Pre-requisites

                    Please contact Prof. Dr. O. Daumke (oliver.daumke@mdc-berlin.de) if you would like to participate.

                    Comments

                    Content:
                    Journal-club seminars on various topics in structural biology, including:
                    

                    • new X-ray, NMR and cryo-EM structures
                    • method developments in macromolecular crystallography
                    • method developments in cryo-electron microscopy
                    • new concepts in molecular and cell biology
                    • current studies in membrane biology
                    • current studies in gene expression regulation
                    • structure-based identification and optimization of chemical probes
                    
                    Contact:
                    
                    Prof. Dr. O. Daumke: oliver.daumke@mdc-berlin.de

                  • 216501a Lecture
                    Membrane Proteins: Classification, Structure and Function (Stefan Kubick)
                    Schedule: Di 18:00 st. - 19:00 h (Class starts on: 2025-10-14)
                    Location: Hs Biochemie, Thielallee 63 (Lise-Meitner-Hörsaal)
                    

                    Information for students

                    Registration for the lecture by email to: stefan.kubick@fu-berlin.de) Then you will receive the access data. Classes 216501 a and b must be attended together. Their succesfull completion is obligatory for the application for the method module 216451 a, b!

                    Comments

                    Content:
                    Biomembranes and synthesis of transmembrane proteins:
                    

                    • Molecular structure of membranes
                    • Synthesis of biomembranes
                    • Lipid rafts
                    • Subcellular organization of the eukaryotic cell, cell metabolism and secretion
                    • Protein synthesis
                    
                    Receptors and signal transduction:
                    
                    • Cell surface receptors
                    • Signal transduction pathways
                    
                    Multigene families encoding membrane proteins:
                    
                    • G protein-coupled receptors (structure, signal transduction, agonists/antagonists)
                    • Odorant receptors
                    • Non-peptide receptors
                    • Peptide receptors
                    
                    Ion channels:
                    
                    • voltage-gated ion channels
                    • ligand-gated ion channels
                    • mechanosensitive ion channels
                    
                    Methods in molecular biology and protein chemistry:
                    
                    • Production of membrane proteins
                    • Cell-free protein synthesis (prokaryotic systems, eukaryotic systems, labeling)
                    • Structural and functional analysis of membrane proteins
                    
                    
                    Dr. S. Kubick: stefan.kubick@fu-berlin.de
                    

                  • 216501b Seminar
                    Membrane Proteins: Classification, Structure and Function (Stefan Kubick)
                    Schedule: Di 19:00 - 20:00 h (Class starts on: 2025-10-14)
                    Location: Hs Biochemie, Thielallee 63 (Lise-Meitner-Hörsaal)
                    

                    Information for students

                    Registration for the lecture by email to: stefan.kubick@fu-berlin.de) Then you will receive the access data Classes 216501 a and b must be attended together. Their succesfull completion is obligatory for the application for the method module 216451 a, b!

                    Comments

                    Inhalt / Content:
                    Intended for graduate students, this seminar will introduce the tools of membrane protein synthesis and their functional characterization. Membrane proteins account for more than 30% of the genome in living organisms and many membrane-embedded receptors, transporters and ion channels are important therapeutic targets. In this context, methodologies concerning the functional characterization, the structure and the biochemical properties of membrane proteins, their regulation and their physiological relevance are in the focus of this seminar. Emphasis is given to topics that will be useful in other disciplines, including systems for the in vivo and in vitro expression of membrane proteins. The seminar gives a detailed introduction on problems concerning the interaction of chemical messengers with specific cell-surface receptors, the activation of signal-transduction cascades leading to the accumulation of specific intracellular second messenger molecules and the cell’s response to an external stimulus. Beside others the following topics are discussed in detail: Ligand-gated ion channels and their signaling between electrically excitable cells; G protein-coupled receptors, triggering downstream signal transduction cascades, thereby activating separate membrane-associated enzymes and catalytic receptors, acting as enzymes themselves. A critical approach to lipid-membrane protein interactions and the pharmacological properties of selected membrane proteins is also in the focus of this seminar.
                    
                    Seminar takes place right after the lecture (s. above)
                    
                    Dr. S. Kubick: stefan.kubick@fu-berlin.de
                    Fraunhofer Institut für Zelltherapie und Immunologie (IZI), Institutsteil Bioanalytik und Bioprozesse(IZI-BB) Potsdam-Golm, Am Mühlenberg 13, 14476 Potsdam

                  • 216506 Seminar
                    Current Topics in Protein Biochemistry (Christian Freund)
                    Schedule: please contact the instructor for further information
                    Location: Seminarraum 021 (AG Freund), Thielallee 63
                    

                    Comments

                    Inhalt / Content:
                    

                    • Novel enzymes, unconventional catalysts
                    • Proteins in T cell activation and signaling
                    • Synaptic proteins and their interactions
                    • Actin regulatory proteins
                    • Proline-rich sequence (PRS) recognition domain containing proteins
                    
                    
                    Prof. Dr. C. Freund: chfreund@zedat.fu-berlin.de

                  • 216531 Seminar
                    Introduction to Epigenomics (Alexander Meissner)
                    Schedule: Thursday, 15.01.26 (9.30 - 17:00 h) and Friday 16.01.26 ( 09:30 - 16:00 h)
                    Location: MPIMG, Ihnestr. 63, Seminarraum S3, 14195 Berlin
                    

                    Information for students

                    Seminar is only in English.

                    Additional information / Pre-requisites

                    Comments

                    Content:
                    Chemical modifications to DNA and histone proteins form a complex regulatory network that modulates chromatin structure and genome function. The epigenome refers to the complete description of these potentially heritable changes across the genome. The composition of the epigenome within a given cell is a function of genetic determinants, lineage, and environment. With the sequencing of the human genome completed, investigators now seek a comprehensive view of the epigenetic changes that determine how genetic information is made manifest across an incredibly varied background of developmental stages, tissue types, and disease states.
                    Aim of the seminar is to provide a basic introduction to epigenetics including an overview and basic understanding of key technologies that produce today’s epigenomic data. On the second day basic data processing and analysis will be covered.
                    
                    Thursday: Introduction to Epigenetics Introduction to Next-Generation Sequencing Key technologies: DNA methylation mapping, Chromatin mapping, 3D architecture, long read sequencing Isolation of high molecular weight DNA (for long read sequencing), state-of-the-art library generation and QC, Sequencing Friday: From DNA sequencer to data analysis Nanopore sequencing and analysis (Epi)-Genome browsing Epigenetic deregulation in disease Prof. Dr. A Meißner: meissner@molgen.mpg.de

                  • 216542 Lecture
                    Emerging Viruses (Susann Kummer)
                    Schedule: 05.11. - 07.11.25, 12.11. - 14.11.25 and 19.11.-20.11.25 from 09:30 - 11.00 h
                    Location: Online - zeitABhängig
                    

                    Information for students

                    If you would like to participate please write to Dr. Susann Kummer: susann.kummer@fu-berlin.de

                    Comments

                    Description:
                    Introduction into principles of emerging viruses. The lecture will address the definition and description of emerging viruses and processes behind the development of emerging diseases. In the following examples of emerging viruses will be presented and their risk potential discussed. The topic of pandemic events, health care measures and ways to prevent and/or handle future pandemics will be part of the lecture series as well.
                    
                    1) Introduction, what are emerging viruses, what is an endemic/pandemic, history of pandemics and what we can learn from the past
                    2) Influenza viruses
                    3) SARS and MERS related corona viruses
                    4) Ebola viruses
                    5) human immunodeficiency viruses
                    6) Mosquito-transmitted viruses (ZIKA, Dengue, West Nile virus, Chikungunya, Yellow fever)
                    7) Emerging diseases in animals (risk potential for transfer to humans)
                    8) Emerging marine viruses and conclusions, open discussion, Q & A session to virus research related topics

                  • 216703 Seminar
                    Journal Club "Recent Topics in Signaltransduction" (Petra Knaus)
                    Schedule: expected to take place regularly on Thursdays, 9:30am (Hybrid format) please contact the instructor for further information.
                    Location: Thielallee 63, room 221 (Knaus group) and Online - zeitABhängig
                    
                  • 216709a Seminar
                    (S) Methods of Science Communication (Jerome Jatzlau)
                    Schedule: Takes place regularly on Tuesdays or Wednesdays, 18:00 h on site, please contact the instructor for further information. First Meeting: 15.10.2025
                    Location: Thielallee 63, Raum 221 (AG Knaus)
                    

                    Information for students

                    Seminar is open for both Bachelor and Master students independent of the semester. It is recommended to visit the course towards the end of the Bachelor studies or within the Master studies. Seminar will be on german or english. For registration send an e-mail to: jerome.jatzlau@fu-berlin.de with your name and your FU Student ID Nummer.

                    Comments

                    Content:
                    Students will get to known key aspects of good scientific communication. Further they will get to know different creative methods to express and communicate their scientific results to peers and the broader public. From the different methods students should select two to further explore and apply to a topic of their choice. This could be used as a preparation for any lab presentation of a research project or using a topic handed out by the instructors.
                    Methods include:
                    
                    • Science Slam
                    • 3D printing of scientific models
                    • 3D rendering & animation ( proteins, DNA, membranes, cells)
                    • Memes as vehicle of science communication
                    • Artifical intelligence for scientific graphic rendering
                    
                    Dr. J. Jatzlau: jerome.jatzlau@fu-berlin.de; L. Obendorf: leon.obendorf@fu-berlin.de
                    
                    

                  • 216709b Seminar
                    (P) Methods of Science Communication (Jerome Jatzlau)
                    Schedule: In preparation for the following week, course participants work on a practical creative project at home. The time required varies depending on the subject area. First date: 15.10.2025
                    Location: Thielallee 63, Raum 221 (AG Knaus)
                    

                    Information for students

                    Seminar is open for both Bachelor and Master students independent of the semester. It is recommended to visit the course towards the end of the Bachelor studies or within the Master studies. Seminar will be on german or english. For registration send an e-mail to: jerome.jatzlau@fu-berlin.de with your name and your FU Student ID Nummer.

                    Comments

                    Content:
                    Presentation of the chosen project.
                    Methods include:
                    
                    • Science Slam
                    • 3D printing of scientific models
                    • 3D rendering & animation ( proteins, DNA, membranes, cells)
                    • Memes as vehicle of science communication
                    • Artifical intelligence for scientific graphic rendering
                    
                    Dr. J. Jatzlau: jerome.jatzlau@fu-berlin.de; L. Obendorf: leon.obendorf@fu-berlin.de
                    
                    

                  • 216711a Seminar
                    Stem Cell Biology (Nan Ma)
                    Schedule: 13.10. - 10.11.2025, every Monday, 15:00 -19:00 h (Class starts on: 2025-10-13)
                    Location: PC-Pool Chemie (Raum A.-106, UG1) (Arnimallee 22)
                    

                    Information for students

                    Seminars 216711a and b must be attended together
                    For application directly contact the lecturer: Prof Dr. Nan Ma: nan.ma@fu-berlin.de

                    Comments

                    Content:
                    

                    • Stem cell and regenerative medicine
                    • Adult stem cell
                    • Embryonic stem cell
                    • Induced pluripotent stem cell
                    • Stem cell niche
                    • Technique of purification and characterization(FACS)
                    
                    
                    Prof. Dr. N. Ma: Nan.Ma@fu-berlin.de

                  • 216711b Seminar
                    Stem Cell Therapy (Nan Ma)
                    Schedule: 17.11.25 - 15.12.25 every monday, 15:00 -19:00 h (Class starts on: 2025-11-17)
                    Location: PC-Pool Chemie (Raum A.-106, UG1) (Arnimallee 22)
                    

                    Information for students

                    Seminars 216711a and b must be attended together
                    For application directly contact the lecturer: Prof Dr. Nan Ma: nan.ma@hereon.de

                    Comments

                    Content:
                    

                    • The basic of stem cell transplantation
                    • Hematopoietic stem cell transplantation(HSCT)
                    • Cancer stem cell and targeted therapy
                    • Skin stem cell and their clinical application
                    • Stem cell and cardiac repair
                    
                    
                    Prof Dr. N. Ma,: Nan.Ma@hzg.de

                  • 216741a Seminar
                    Molecular Virology (Annette Mankertz; Joachim Mankertz)
                    Schedule: Briefing: 15.10.25, 17:00 h Wednesday 17:00-18:30 h (a: 17:00 - 17:45 h, b: 17:45-18:30 h)
                    Location: Onlinelehre – zeitABhängig. Powerpoint with voice-over and/or videoconference at the regular time.
                    

                    Information for students

                    Given via video conference, interested students may enlist via E-Mail to mankertza@rki.de
                    
                    Seminars 216741a and b must be attended together
                    Some dates of the event may take place online
                    

                    Comments

                    Content: 45 min introduction to the topic by lecturer 15 min presentation of a paper by student with slides (plus 2 pages handout sent to all students) 30 min seminar with questions on specific points of the presentation and the lecture, discussion Prof. Dr. A. Prof. Dr. A. Mankertz:mankertza@rki.de
                    PD Dr. J. Mankertz:joachim.mankertz@bvl.bund.de

                  • 216741b Seminar
                    Spezielle molekulare Virologie (Annette Mankertz; Joachim Mankertz)
                    Schedule: Briefing: 15.10.25, 17:00 h Wednesday 17:00-18:30 h (a: 17:00 - 17:45 h, b: 17:45-18:30 h)
                    Location: Onlinelehre – zeitABhängig. Powerpoint with voice-over and/or videoconference at the regular time.
                    

                    Information for students

                    Seminars 216741a and b must be attended together Given via video conference, interested students may enlist via E-Mail to mankertza@rki.de

                    Comments

                    Content: 45 min introduction to the topic by lecturer 15 min presentation of a paper by student with slides (plus 2 pages handout sent to all students) 30 min seminar with questions on specific points of the presentation and the lecture, discussion Given via video conference, interested students may enlist via E-Mail to mankertza@rki.de
                    
                    Prof. Dr. A. Mankertz:mankertza@rki.de
                    PD Dr. J. Mankertz:joachim.mankertz@bvl.bund.de

                  • 216762 Seminar
                    The Drug Discovery Process in the Pharmaceutical Industry - From target to hit identification (Roman Hillig, Holger Steuber)
                    Schedule: Schedule: Di and Do, 08:00 - 09:30 h, duration: 04.11.25 - 27.11.25
                    Location: Online - zeitABhängig. Vertonte ppt und/oder Videokonferenz zur regulären Zeit.
                    

                    Information for students

                    Die Teile (I im SS und II im WS) können in beliebiger Reihenfolge besucht werden, sie sind nicht aufbauend.

                    Additional information / Pre-requisites

                    Seminars 216761 and 216762 can be attended in arbitrary sequence, they do not build-up on each other.

                    Comments

                    Content:
                    1. Target Identification and Hit Finding
                    2. X-ray Crystallography in DD
                    3. Molecular Modeling
                    4. Fragment-Based Drug Design
                    5. New Modalities, New target Classes
                    6. Target Class: Ras GTPase superfamily
                    7. Target Class: Epigenetic Targets
                    8. Nuclear Magnetic Resonance
                    
                    Dr. R. Hillig: roman.hillig@nuvisan.com
                    Dr. H. Steuber: holger.steuber@ nuvisan.com

                • Modules w/o courses in this semester

                  33 Modules
                  • Methods module (5 LP) 0390bB1.10
                  • Methods module of an affine subject (5 LP) 0390bB1.8
                  • Methods module (5 LP) 0390bB1.9
                  • Research Project A (15 LP) 0390bB2.10
                  • Research Project in Molecular Biology A (15 LP) 0390bB2.3
                  • Research Project in Structural Biology and Biophysics A (15 LP) 0390bB2.4
                  • Research Project in Molecular Genetics A (15 LP) 0390bB2.5
                  • Research Project in Cell Biology A (15 LP) 0390bB2.6
                  • Research Project in Computational Biology, Bioinformatics and Data Analysis A (15 LP) 0390bB2.7
                  • Research Project in Molecular Biomedicine A (15 LP) 0390bB2.8
                  • Supervised research - affine subject A (15 LP) 0390bB2.9
                  • Research Project in Molecular Biology B (10 LP) 0390bB3.1
                  • Research Project in Computational Biology, Bioinformatics and Data Analysis C (5 LP) 0390bB3.10
                  • Research Project in Molecular Biomedicine B (10 LP) 0390bB3.11
                  • Research Project in Molecular Biomedicine C (5 LP) 0390bB3.12
                  • Special Aspects of Biochemistry A (5 LP) 0390bB3.14
                  • Special Aspects of Biochemistry B (5 LP) 0390bB3.15
                  • Special Aspects of Biochemistry C (5 LP) 0390bB3.16
                  • Special Aspects of Biochemistry D (5 LP) 0390bB3.17
                  • Teaching in Biochemistry (5 LP) 0390bB3.18
                  • Supervised research - affine subject B (10 LP) 0390bB3.19
                  • Research Project in Molecular Biology C (5 LP) 0390bB3.2
                  • Research Project B (10 LP) 0390bB3.20
                  • Supervised research - affine subject C (5 LP) 0390bB3.21
                  • Research Project C (5 LP) 0390bB3.22
                  • Research Project in Structural Biology and Biophysics B (10 LP) 0390bB3.3
                  • Research Project in Structural Biology and Biophysics C (5 LP) 0390bB3.4
                  • Research Project in Molecular Genetics B (10 LP) 0390bB3.5
                  • Research Project in Molecular Genetics C (5 LP) 0390bB3.6
                  • Research Project in Cell Biology B (10 LP) 0390bB3.7
                  • Research Project in Cell Biology C (5 LP) 0390bB3.8
                  • Research Project in Computational Biology, Bioinformatics and Data Analysis B (10 LP) 0390bB3.9
                  • Free elective module (10 LP) 0390bB4.3