The Bottanelli lab employs super-resolution imaging techniques to understand how sorting along the secretory pathway of mammalian cells is realized at the nanoscale level. Cell homeostasis, differentiation and development rely on the fidelity of these processes and despite significant advances in identifying the machinery and molecular mechanisms involved in cargo sorting in vitro, it is still unclear how sorting is spatio-temporally achieved in vivo. For previous work of the group leader please check the Google scholar page: https://scholar.google.com/citations?hl=en&user=6MbjQGUAAAAJ&view_op=list_works&sortby=pubdate).
In particular, we use gene editing and stimulated emission depletion (STED) nanoscopy to understand how molecular switches (GTPases) dynamically regulate the recruitment of scaffolds and the formation of sorting nano-domains at the trans-Golgi network (TGN), one of the main cellular sorting station.
University degree (Master) in biology, biochemistry, biophysics or related subjects.
Candidates are expected to have a strong interest in the investigation of intracellular trafficking and imaging. Motivation, ability to work in a collaborative environment and communication skills (in English) are essential. Prior experience in mammalian cell culture, molecular biology and imaging is desirable.
Please apply by sending your CV, a short description of your Masters project/research experience and the contact information of two referees to email@example.com. Please cite reference number 213462000/51/18.
For more information please contact Prof. Dr. Francesca Bottanelli (firstname.lastname@example.org / +493083865860).