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Project Summary:

Premature vascular progeria under chronic uremia: influence of toll-like receptor-mediated NLRP3 inflammasome dependent inflammaging

Development of chronic kidney disease is associated with an increase in all-cause mortality due to uremic syndrome. As part of this, premature senescence and phenotype transformation of vascular smooth muscle cells with associated primary vascular calcification are typical phenomenon comparable to processes of normal aging. Like this, uremic vascular progeria is caused by inflammaging. The aim of our project is the exploration of the influence of uremic toxins on NLRP3 inflammasome activation as trigger of uremic inflammaging and the development of novel therapeutic options.

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