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Project Summary:

A Quantitative Approach to Extracellular Matrix (ECM) Function in Aged Muscle Regeneration

Aging and associated metabolic co-morbidities such as obesity inhibit the regenerative abilities of skeletal muscle, resulting in compromised healing associated with adipocyte infiltration and fibrosis. By combining biological readouts and mathematical modeling we will analyze how aging and obesity impact on the biomechanical properties of the muscle stem cell niche to achieve a new level of understanding of ageing processes prospectively transferable to muscle-degenerative disorders.