3. Age-dependent mechanoresponsiveness of BMP signaling
Prof. Dr. Petra Knaus (Principal Investigator FUB)
Dr. Sven Geißler (Principal Investigator CUB)
Dr. Tobias Stauber (FUB), Dr. Maria Reichenbach (FUB)
Mechanical stimuli together with bone morphogenetic proteins (BMPs) trigger bone formation facilitating adaption towards forces. With increasing age this adaptive response is blunted and bone mass and strength declines, while prevalence of fractures increases. However, recent studies suggest that age-related changes in mechano-responsiveness of bone forming cells largely contribute to declined bone formation. Therefore, we aim to elucidate the interplay between BMP signaling and mechanotransduction as well as their age-related changes using RNA Sequencing.