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1. Novel multivariate biomarkers of age-dependent sarcopenia: A blood based bioenergetics & cytokine profiling approach

Principal Investigators:

Dr. Mario Ost (Principal Investigator, DIfE, Section Physiology of Energy Metabolism, Potsdam-Rehbrücke),

Prof. Ursula Müller-Werdan (Principal Investigator, CUB: Universitätsmedizin Charité Berlin, Evangelisches Geriatriezentrum/EGZB gGmbH) 

Collaborating Researchers:

Prof. Susanne Klaus (DIfE),

PD Dr. Kristina Norman (CUB, Campus Virchow-Klinikum, Internal Medicine with Gastroenterology and Nephrology CC 13, Nutrition and Body Composition/Berlin Aging Study II),

Prof. Andreas Pfeiffer (DIfE, Department of Clinical Nutrition, Potsdam-Rehbrücke),

Prof. Tim J. Schulz (DIfE, Department of Adipocyte Development and Nutrition, Potsdam-Rehbrücke)

Project Summary:

A hallmark of advanced ageing in humans is sarcopenia, an age-related loss of skeletal muscle mass and strength. However, biomarkers of sarcopenia and key molecular mechanisms are still lacking. The goal of this research project is to investigate the association of age-related sarcopenia with mitochondrial dysfunction and inflammation. We will combine studies of human blood samples from geriatric individuals with studies of mouse samples in order to identify robust biomarkers for evaluating the progression of age-dependent sarcopenia and to uncover novel therapeutic targets.