Xiaonan Ma received his doctorate degree at Institute of Chemistry, Chinese Academy of Sciences in summer of 2011. In PhD program, his research mainly focused on the development of femtosecond time-resolved spectroscopic techniques, such methods were further employed to investigate ultrafast photoinduced intra- and intermolecular dynamics of complex chromophores combined with theoretical approach. He also participated in a collaborated research on nonlinear optical property of hollow core fiber and few-cycle laser generation. In beginning of 2012, he was selected as a Dahlem Research School (DRS) POINT fellow to perform postdoctoral research on membrane protein at the department of Physics of Freie Universität Berlin.
Focus of Research
Time-resolved spectroscopy, Functionality of membrane protein monolayer, Laser physics and nonlinear optics
Postdoctoral Research Project
Time-resolved FTIR spectroscopy on solid-supported membrane proteins
A membrane protein is a protein molecule that is attached to, or associated with the membrane of a cell or an organelle. The function of membrane proteins, particularly of ion channels, is critically dependent on the conformation of the protein backbone. To explore conformational changes of light-gated ion channels (such as channelrhodopsin-2) upon optical excitation in atomic level, state-of-the-art vibrational spectroscopy with high sensitivity and time-resolved capability will be used. The study will not only try to trace protein backbone structural alterations between several different photointermediates but also on the hydrogen-bonding changes and their influence on the function of channels. The department of Physics of the Freie Universität Berlin is a particular place for this kind of research because of their focus on biophysics and the unique network of sophisticated facilities that can be used by young researchers. In the end, this research project will contribute to the mechanistic understanding of the function of membrane proteins. As more than 50% of all pharmaceutical drugs act on membrane proteins, such mechanistic knowledge will eventually lead to the development of improved drugs.
Recently Published Papers
(1) Ma, X. N., Yan, L. Y., Wang, X. F., Guo, Q. J. and Xia, A. D. (2011): Determination of the Hydrogen-Bonding Induced Local Viscosity Enhancement in Room Temperature Ionic Liquids via Femtosecond Time-Resolved Depleted Spontaneous Emission. J. Phys. Chem. A 115, 7937-7947.
(2) Ma, X. N., Yan, L. Y., Wang, X. F., Guo, Q. J. and Xia, A. D. (2011): Spectral and Intramolecular Charge Transfer properties of Terminal Donor/Acceptor-Substituted all-trans-α,ω-Diphenylpolyenes and α,ω-Diphenylpolyynes. Phys. Chem. Chem. Phys. 13, 17273-17283.
(3) Jia, M. L., Ma, X. N., Yan, L. Y., Wang, H. F., Guo, Q. J., Wang, X. F., Wang, Y. Y., Zhan, X. W. and Xia, A. D. (2010): Photophysical properties of intramolecular charge transfer in two newly synthesized tribranched donor-π-acceptor chromophores. J. Phys. Chem. A 114, 7345-7352.
(4) Wang, Y. Y., Ma, X. N., Vdović, S., Yan, L. Y., Wang, X. F., Guo, Q. J. and Xia, A. D. (2011): Photophysical property of photoactive molecules with multibranched push-pull structures. Chin. J. Chem. Phys. 24, 563-571.
(5) Wan, Y., Yan, L. Y., Zhao, Z. J., Ma, X. N., Guo, Q. J., Jia, M. L., Lu, P., Ramos-Ortiz, G., Maldonado, J. L., Rodríguez, M. and Xia, A. D. (2010): Gigantic two-photon absorption cross sections and strong two-photon excited fluorescence in pyrene core dendrimers with fluorene / carbazole as dendrons, and acetylene as linkages. J. Phys. Chem. B 114, 11737-11745.