News vom 28.07.2017
Natural covalent nucleic acid modifications form a new hidden layer of information in the genetic code beyond the classical four letter alphabet. The Priority Programme was established to unravel this code. A network of researchers with backgrounds in chemical biology, structural biology, enzymology and bioinformatics will gain deeper insight into where, how and why native nucleic acid modifications occur and how they influence cellular processes. Prospective participants will address current challenges in detection, localisation, recognition, and function of naturally occurring modifications in RNA and DNA. Modifications as defined in the programme, are specifically introduced to the nucleic acid by cognate enzymes, and do not include chemical lesions, DNA or RNA damages inflicted by light, reactive oxygen species, chemicals, and the like.
Projects to be funded within the frame of the Priority Programme need to address scientific questions at the atomic resolution level, using approaches of chemical biology, and biochemistry or structural biology.