Elsaesser Dr., Andreas - POINT Fellow

Portrait Elsaesser

NanoScale

Experimental Molecular Biophysics

Address
Arnimallee 14
14195 Berlin

After his studies in physics at the Technical University Munich, Dr. Andreas Elsaesser received his PhD in Biophysics from the University of Ulster, UK, in 2012, followed by a postdoctoral research position at Leiden University, NL. Since November 2015, Dr. Elsaesser is an FU Berlin POINT fellow within the focus area Nanoscale.

The research curriculum of Dr. Andreas Elsaesser is dominated by research projects with a highly multidisciplinary character. During his PhD. Dr. Elsaesser focused on the interaction of electromagnetic radiation and biological systems in the presence of nano-particulate matter. Soon after he worked in the field of astrochemistry and space research while still studying basic interaction mechanisms between biology and radiation. One of his strong interests is to understand the photostability of organic molecules and potential biomarkers relevant for the search for life on Earth and on other planets in our solar system. Dr. Elsaesser is currently involved in several projects on the International Space Station and collaborates with colleagues from the German Aerospace Center, the European Space Agency and NASA. His current research at FU Berlin includes studying the photostability of membranes and membrane molecules on the nanoscale by employing superresolution near-field optical microscopy and infrared spectroscopy, which allows to combine nanoscale spatial resolution and chemical mapping.

[1]    Demets, R., Bertrand, M., Bolkhovitinov, A., Bryson, K., Colas, C., Cottin, H., Dettmann, J., Ehrenfreund, P., Elsaesser, A., Jaramillo, E. & others. Window contamination on Expose-R. Int. J. Astrobiol. 14, 33–45 (2015).

[2]    Bryson, K. L., Salama, F., Elsaesser, A., Peeters, Z., Ricco, A. J., Foing, B. H. & Goreva, Y. First results of the ORGANIC experiment on EXPOSE-R on the ISS. Int. J. Astrobiol. 14, 55–66 (2015).

[3]    Elsaesser, A., Quinn, R. C., Ehrenfreund, P., Mattioda, A. L., Ricco, A. J., Alonzo, J., Breitenbach, A., Chan, Y. K., Fresneau, A., Salama, F. & Santos, O. Organics Exposure in Orbit (OREOcube): A Next-Generation Space Exposure Platform. Langmuir 30, 13217-27 (2014). ACS Editor´s Choice

[4]    Perfumo, A., Elsaesser, A., Littmann, S., Foster, R. a, Kuypers, M. M. M., Cockell, C. S. & Kminek, G. Epifluorescence, SEM, TEM and nanoSIMS image analysis of the cold phenotype of Clostridium psychrophilum at subzero temperatures. FEMS Microbiol. Ecol. 90, 869-882 (2014). Chief Editor´s Choice

[5]    Aerts, J. W., Röling, W. F. M., Elsaesser, A. & Ehrenfreund, P. Biota and biomolecules in extreme environments on Earth: implications for life detection on Mars. Life 4, 535–65 (2014).

[6]    Cook, A. M., Mattioda, A. L., Ricco, A. J., Quinn, R. C., Elsaesser, A., Ehrenfreund, P., Ricca, A., Jones, N. C. & Hoffmann, S. V. The Organism/Organic Exposure to Orbital Stresses (O/OREOS) Satellite: Radiation Exposure in Low-Earth Orbit and Supporting Laboratory Studies of Iron Tetraphenylporphyrin Chloride. Astrobiology 14, 87–101 (2014).

[7]    Van Hoecke, K., De Schamphelaere, K. A. C., Ali, Z., Zhang, F., Elsaesser, A., Rivera-Gil, P., Parak, W. J., Smagghe, G., Howard, C. V & Janssen, C. R. Ecotoxicity and uptake of polymer coated gold nanoparticles. Nanotoxicology 7, 37–47 (2013).

[8]    Kim, E.-M., Palmer, P., Howard, V., Elsaesser, A., Taylor, A., Staats, G. & O’Hare, E. Effect of Intracerebroventricular Injection of TiO2 Nanoparticles on Complex Behaviour in the Rat. J. Nanosci. Nanotechnol. 13, 8325–8330 (2013).

[9]    Elsaesser, A. & Howard, C. V. Toxicology of nanoparticles. Adv. Drug Deliv. Rev. 64, 129–137 (2012).

[10] De Vera, J.-P., Boettger, U., de la Torre Noetzel, R., Sánchez, F. J., Grunow, D., Schmitz, N., Lange, C., Hübers, H.-W., Billi, D., Baqué, M. & others. Supporting Mars exploration: BIOMEX in Low Earth Orbit and further astrobiological studies on the Moon using Raman and PanCam technology. Planet. Space Sci. 74, 103–110 (2012).

[11] Park, M. V. D. Z., Verharen, H. W., Zwart, E., Hernandez, L. G., van Benthem, J., Elsaesser, A., Barnes, C., McKerr, G., Howard, C. V., Salvati, A. & others. Genotoxicity evaluation of amorphous silica nanoparticles of different sizes using the micronucleus and the plasmid lacZ gene mutation assay. Nanotoxicology 5, 168–181 (2011).

[12] Park, M. V. D. Z., Lynch, I., Ramírez-García, S., Dawson, K. A., de la Fonteyne, L., Gremmer, E., Slob, W., Briedé, J. J., Elsaesser, A., Howard, C. V. & others. In vitro evaluation of cytotoxic and inflammatory properties of silica nanoparticles of different sizes in murine RAW 264.7 macrophages. J. Nanoparticle Res. 13, 6775–6787 (2011).

[13] Elsaesser, A., Barnes, C. A., McKerr, G., Salvati, A., Lynch, I., Dawson, K. A. & Howard, C. V. Quantification of nanoparticle uptake by cells using an unbiased sampling method and electron microscopy. Nanomedicine 6, 1189–1198 (2011).

[14] Perfumo, A., Cockell, C., Elsaesser, A., Marchant, R. & Kminek, G. Microbial diversity in Calamita ferromagnetic sand. Environ. Microbiol. Rep. 3, 483–490 (2011).

[15] Hazekamp, J., Doherty, S., Elsaesser, A., Barnes, C. A., O’HAGAN, B. M. G., McKerr, G. & Howard, C. V. Focussed ion beam milling at grazing incidence angles. J. Microsc. 242, 104–110 (2011).

[16] Elsaesser, A., Taylor, A., de Yanés, G. S., McKerr, G., Kim, E.-M., O’Hare, E. & Howard, C. V. Quantification of nanoparticle uptake by cells using microscopical and analytical techniques. Nanomedicine 5, 1447–1457 (2010).

[17] Hoecke, K. Van, Quik, J. T. K., Mankiewicz-Boczek, J., Schamphelaere, K. A. C. De, Elsaesser, A., Meeren, P. Van der, Barnes, C., McKerr, G., Howard, C. V., Meent, D. Van De & others. Fate and effects of CeO2 nanoparticles in aquatic ecotoxicity tests. Environ. Sci. Technol. 43, 4537–4546 (2009).

[18] Park, M. V. D. Z., Annema, W., Salvati, A., Lesniak, A., Elsaesser, A., Barnes, C., McKerr, G., Howard, C. V., Lynch, I., Dawson, K. A. & others. In vitro developmental toxicity test detects inhibition of stem cell differentiation by silica nanoparticles. Toxicol. Appl. Pharmacol. 240, 108–116 (2009).

[19] Barnes, C. A., Elsaesser, A., Arkusz, J., Smok, A., Palus, J., Lesniak, A., Salvati, A., Hanrahan, J. P., Jong, W. H. de, Dziuba\ltowska, E. & others. Reproducible comet assay of amorphous silica nanoparticles detects no genotoxicity. Nano Lett. 8, 3069–3074 (2008).

[20] Samsonov, D., Elsaesser, A., Edwards, A., Thomas, H. M. & Morfill, G. E. High speed laser tomography system. Rev. Sci. Instrum. 79, 35102 (2008).