The surface of the gastrointestinal tract represents the largest area where the organism interacts with the surrounding environment. At this interface of the body a highly sophisticated immune system recognizes a variety of endogenous bacteria or food antigens.
The SFB 633, in which the Research Training Group IMMUCO is integrated, focuses on the analyses of the specific conditions of mucosal T-cell activation and differentiation that eventually define the quality of immune responses. A variety of research groups cooperate within the SFB 633 to develop perspectives and therapeutical strategies, supporting protective immune responses and suppressing chronical inflammations. Whereas some groups aim to clarify basic mechanisms others focus on disease- and patient-related approaches. Experimental approaches range from in vitro studies or animal models to clinical applications.