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5. Anti-neuronal antibodies and further (neuro-) biological correlates of Post-operative cognitive dysfunction (POCD)

PD Dr. Harald Prüß (Principle Investigator CUB, Klinik für Neurologie)

Prof. Dr. Gerhard Wolber (Principle Investigator FUB, FB Biologie, Chemie, Pharmazie)


Collaborating Researchers: Prof. Dr. Maria Kristina Parr (FUB); PD Dr. Oliver Peters (CUB); Dr. Bettina Bert (FUB); Prof. Dr. Frank Heppner (CUB); Prof. Dr. Isabella Heuser (CUB); Prof. Dr. Christoph Stein (CUB)

Project Summary

Post-operative cognitive dysfunction (POCD) is an increasingly recognized condition with high morbidity. Autoimmune mechanisms might contribute to the disease by interfering with blood-brain barrier function and generation of anti-neuronal antibodies. The project aims to identify the frequency of treatable auto-antibodies in POCD patients, and analyzes possible biomarkers for the development of cognitive decline using nuclear magnetic resonance and mass spectrometry.