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8. (Neuro-)biological correlates of post-operative cognitive dysfunction (POCD)

Prof. Dr. M. K. Parr (Principle Investigator FUB, FB Biologie, Chemie, Pharmazie)

Dr. O. Peters (Principle Investigator CUB, Klinik für Psychiatrie und Psychotherapie)

Collaborating Researchers: Dr. B. Bert (FUB), Prof. Dr. H. Fink (FUB), Prof. Dr. F. Heppner (CUB), Prof. Dr. I. Heuser (CUB), Prof. Dr. C. Stein (CUB), Prof. Dr. G. Wolber (FUB)


Project Summary

Post-operative cognitive dysfunction (POCD) may affect especially older patients undergoing major surgery. POCD may last for days and weeks or even persist over time. Comparable cognitive deficits may also occur after electroconvulsive therapy (ECT), an effective treatment procedure for pharmacotherapy resistant depression.

Cognitive deficits may even overweigh the positive value of treatment. To assess the individual risk neurobiological correlates and predictors will be studied in a targeted and in a non-targeted design. The human studies will be complemented by mechanistic studies.