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12. Nanoparticulate opioid conjugates for the treatment of chronic pain

Dr. S. Gupta (Principle Investigator FUB, FB Biologie, Chemie, Pharmazie)

Dr. S. González-Rodríguez (Principle Investigator CUB, Klinik für Anästhesiologie und operative Intensivmedizin)

Collaborating Researchers: Prof. Dr. H. Machelska (CUB), Dr. V. Spahn (CUB), Dr. G. Del Vecchio (CUB), Dr. N. Massaly (CUB), X. Zhang (FUB), Prof. Dr. R. Haag (FUB), Prof. Dr. C. Stein (CUB)


Project Summary

Chronic pain associated with inflammatory diseases or cancer is correlated with biological aging and becomes more prevalent in the elderly. Currently, severe pain is treated with opioids (morphine) that elicit adverse side effects mediated in the brain (apnoea, addiction, nausea, sedation, dysphoria). We develop nanoparticulate formulations that do not cross the blood-brain barrier but transport opioids into injured tissue or tumors to activate local opioid receptors. This should avoid central effects and improve treatment of inflammation and pain.