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Nanocarriers for controlled transport of active compounds

Indo-German Research Project

Transport, solubility and selective release of active compounds on the molecular level are very
important for biomedical applications. Hyperbranched aliphatic polyethers like poly(ethylene imine)
and polyglycerol are commercially available in large quantities. These polymers exhibit good chemical
stability and inertness under biological conditions. Through chemical differentiation and selective
functionalization of the terminal groups it is possible to convert these polymers into core-shell
structures. These core-shell architectures are relatively stable under physiological conditions (neutral
environment) and only cleave on exposure of external stimuli, e.g., acidic environment or enzyme, in
which case the active substance is released. In this collaboration project the synthetic expertise on
bioactive compounds and enzymatic reactions, etc. from the University of Delhi and the
macromolecular expertise from the Freie Universität Berlin are combined to investigate new
bioactive compounds for drug delivery.

For further information, please see (Prof. R. Haag) (Prof. S. Sharma) (Prof. AK Prasad)