Their Role in Protein Folding and Neurodegenerative Disease
In cooperation with the Freie Universität Berlin the Schering Stiftung presents a Public Lecture by Professor Dr. Franz-Ulrich Hartl that addresses scientists and students.
Proteins perform a variety of essential tasks in all cells of our body. In order to fulfill their biological functions, these chain-like molecules must fold into specific three-dimensional patterns. This process was originally thought to occur spontaneously. However, work by Prof. Dr. Franz-Ulrich Hartl, director of the Cellular Biochemistry Department at the Max Planck Institute of Biochemistry in Martinsried, showed that in our cells protein folding is mediated by helper molecules. These helper molecules are called chaperones, since these molecules make sure that proteins behave, i.e. fold, correctly. Incorrectly folded proteins tend to clump together to aggregates, which disturb cell functions in various ways and can cause neurodegenerative pathologies, such as Alzheimer’s dementia, Parkinson’s and Huntington’s disease. The insight that age-related diseases are caused by incorrectly folded proteins offers opportunities for novel therapeutic approaches. Prof. Hartl’s current research particularly focuses on these therapeutic approaches.
23.09.2016 | 14:00 - 15:30
Vorlesungssaal Anorganische Chemie (H101)
The lecture will be held in English.
Registration is not required.
Ansprechpartner: Andrea Bölling